Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds.

Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis.

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives.

Green synthetic protocol refers to the development of processes for the sustainable production of chemicals and materials. For the synthesis of various biologically active compounds, energy-efficient and environmentally benign processes are applied, such as microwave irradiation technology, ultrasound-mediated synthesis, photo-catalysis (ultraviolet, visible and infrared irradiation), molecular sieving, grinding and milling techniques, etc. Thesemethods are considered sustainable technology and become valuable green protocol to synthesize new drug molecules as theyprovidenumerous benefits over conventional synthetic methods.

Polyaromatic Hydrocarbons (PAHs): Structures, Synthesis and their Biological Profile.

Polycyclic aromatic hydrocarbons (PAHs) are aromatic compounds with two or more fused benzene rings in their structural configurations. PAHs do not contain heteroatoms and substituents on the ring system. PAHs containing up to four rings are called light PAHs while those that contain more than four rings are considered as heavy PAHs.

Ultrafast Liquid Chromatographic Method Development and its Validation for Quantification of Telaprevir in Pharmaceutical Dosage Form by Using Quality by Design Approach.

Quality by design (QbD) approach thrives to achieve an assured and predicted quality product. A stability-indicating reversed phase ultrafast liquid chromatographic method was developed using the principles of QbD to quantify telaprevir (TEL) in pharmaceutical dosage form. A Box-Behnken experimental design was employed for identifying optimum chromatographic conditions by assessing the method robustness by selecting organic phase composition (%), mobile phase flow rate (mL/min) and pH of the borate buffer as the factors, to study their effect on the responses like retention time, theoretical plate count and tailing factor.