Mechanistic insights of free radical scavenging-driven stabilization of edible oils and their shelf life extension using CeO nanoparticles.

The rapid production of reactive oxygen species (ROS) due to lipid peroxidation of unsaturated bonds in wholesome vegetable oil during its storage and utilization happens to be the most alarming cause of concern in the edible oil industry. In researching for an ideal candidate to be used as an antioxidant, it has been identified that engineered CeO nanoparticle with curated surface chemistry (Ce3+/Ce4+ ratio) displays an enhanced ROS scavenging activity. Herein the CeO nanoparticles (∼100-110 nm) were manufactured though controlled synthesis protocol to achieve the desired outcome.

Paradoxical response during Para-Hisian pacing in a case with fasciculo-ventricular pathway: What is the mechanism?

Causes of paradoxical response include Pure His capture and inadvertent intermittent direct atrial capture. In the index case , we postulate that the likely mechanism of paradoxical prolongation could be due to decrement in the AV node due to the shortening of HH interval which happened as a result of a narrower H + Vc beat .

Metal and acid-free synthesis of acenaphthenone-2-ylidene ketones in PEG 400 and their radical nitration by TBN in water.

The synthesis of acenaphthenone-2-ylidene ketones has been developed using PEG 400 as a solvent under metal and acid-free conditions. Using TBN as a nitrating agent under atmospheric oxygen, nitration of acenaphthenone-2-ylidene ketones has been accomplished for the first time. Upon nitration, ()-2-(2-oxo-2-phenylethylidene)acenaphthylen-1(2)-one and alkyl ()-2-(2-oxoacenaphthylen-1(2)-ylidene)acetate give the diastereomer with the same geometry.

Paradoxical under-sensing of atrial lead at high sensitivity setting in dual chamber pacemaker during atrial flutter - What is the mechanism?

The causes of atrial undersensing in a dual chamber pacemaker include true undersensing (low amplitude electrogram), functional undersensing (related to the effect of special timing cycles in the presence of an adequate signal) and paradoxical undersensing. This case report describes paradoxical atrial undersensing at a higher programmed atrial sensitivity and with the return of normal atrial sensing at a lower programmed sensitivity.

Analysis of intracardiac electrocardiogram during ill-sustained tachycardia - Door to a successful troubleshooting of 'unnecessary' defibrillator discharge.

A 50-year-old gentleman with old anterior wall myocardial infarction with implantable cardioverter defibrillator (ICD, Abbott Medical, Fortify ST VR 1235-40) presented with recurrent appropriate ICD shock. The ICD stored EGM indicated a possibility of supraventricular tachycardia (SVT) rather than ventricular tachycardia (VT) when the morphology match was found high. Bundle brunch re-entry (BBR) VT was another differential.

DMSO promoted catalyst-free oxidative C-N/C-O couplings towards synthesis of imidazoles and oxazoles.

Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C-N coupling and C-O coupling under oxidant-free conditions are outlined. This protocol is operationally simple and leads to various functionalized substituted imidazoles or oxazoles in good yields. To date, a very limited number of oxidation protocols have been established, where DMSO acts solely as a catalyst or an oxidant or both.

Prevalence of polymorphisms in marker genes associated with antimalarial drug resistance in following 10 years of artemisinin-based combination therapy implementation in urban Kolkata.

Context: Resistance to antimalarial drugs is one of the major challenges for malaria elimination. In India, artemisinin combination therapy (artesunate-sulfadoxin pyrimethamine) was introduced in place of chloroquine (CQ) for the treatment of uncomplicated falciparum malaria in 2010. Periodical monitoring of polymorphisms in antimalarial drug resistance marker genes will be useful for assessing drug pressure, mapping and monitoring of drug resistance status; and will be helpful for searching alternative treatments.

Analysing spatio-temporal drought characteristics and copula-based return period in Indian Gangetic Basin (1901-2021).

Uncertainty and uneven distribution of monsoonal rainfall and its consequences on crop production is a matter of serious concern in India, specifically, in the Indo-Gangetic plain region. In this study, drought patterns were investigated through standardised precipitation index (SPI) of varying timescales, using the India Meteorological Department (IMD) precipitation data (1901-2021). We analysed the spatio-temporal pattern of different drought characteristics (frequency, duration, severity, intensity) of the Indian Gangetic basin using run theory.

"On-Off" phenomenon in a case of concealed left lateral atrio-ventricular accessory pathway - What is the mechanism?

We report a case of symptomatic supraventricular tachycardia who had absent VA conduction during electrophysiology study. The interesting finding was appearance of VA conduction only at a specific cycle length of ventricular pacing which reproducibly induced a sustained orthodromic re-entrant tachycardia (ORT). We review the literature and conclude that supernormal AP conduction can explain such phenomenon.

Absent ventriculo-atrial conduction during right ventricular apical pacing but nodal response during para-Hisian pacing - What is the mechanism?

A 13-year-old-girl presented with one episode of pre-syncope while standing in a train. Her ECG was suggestive of preexcitation. Echocardiography revealed structurally normal heart without any ventricular hypertrophy.

Depletion-Guided Engineering of Nanoshell-like Gold Nanocluster Assemblies with Enhanced Peroxidase-like Nanozyme Activity.

Functional superstructures constructed from metal nanoclusters (MNCs) hold great promise in providing highly tunable photoluminescence (PL), catalytic activity, photothermal stability, and biological functionality. However, their controlled synthesis with well-defined size, structure, and properties remains a significant challenge. Herein, we introduce a novel approach that combines depletion attraction and thermal activation to induce the formation of spherical superclusters (AuSCs) from Au(I)-thiolate complexes within the assembly.

Retrograde ventriculoatrial jump-What is the mechanism?

During ventricular extra stimuli(VES) protocol a VA jump was noted. In upper panel with VES @ 500/270 ms (Fig A) the His signal appeared after the A-EGM, ruling out pure nodal VA conduction and confirming presence of an accessory pathway (AP). The H signal was delayed due to probable retrograde RBBB.

Aqueous mediated iodine catalyzed C-N coupling followed by C-C coupling towards 5-pyrazino[2,3-]indoles.

Our study describes a new development featuring iodine-catalyzed two consecutive oxidative cross-coupling reactions involving C(sp)-H of benzyl amines followed by intramolecular cyclization in water under air. Here, C-N coupling followed by C-C coupling occurs in a green environment to provide a variety of 5-pyrazino[2,3-]indoles within a short time period.

Effect of nutritional parameters on microbial production of L-Asparaginase by novel ML12.

L-Asparaginase owes considerable significance in food and pharmaceutical applications. L-Asparaginase is an antineoplastic enzyme that finds application in the treatment of Acute Lymphoblastic Leukemia (ALL) and in mitigating acrylamide (a potent carcinogen) production during baking. In this study, we aimed to optimize nutritional parameters that are significant in initiating and regulating a bioprocess system in order to maximize enzyme production from a novel isolated bacterial species ML12 so the high-yielding enzyme producers can be selected and utilized for better efficacy of this commercially viable enzyme in pharmaceutical field, food industry, in biosensors and as an antioxidant growth kinetics study of the organism was performed and the maximum specific growth rate µ (min) and Monod half saturation constant K for L-Asparagine came out to be µ = 0.

Inappropriate ventricular fibrillation annotation and defibrillator discharge despite the same tachycardia cycle length in ventricular tachycardia-1 zone in an Abbott defibrillator - What is the mechanism?

Newer devices incorporate advanced algorithms to have more accurate delivery of implantable cardioverter-defibrillator (ICD) therapy. Newer models of Abbott Implantable cardioverter-defibrillators like Gallant and Entrant have a new ventricular fibrillation (VF) therapy assurance algorithm. This algorithm has a proven role in avoiding under-detection of VF where some of the smaller electrograms are under-sensed.

An Unusual Genetic Observation in a Case of Short-Coupled PVC-Triggered Ventricular Fibrillation.

Ventricular fibrillation induced by short-coupled premature ventricular complex is an uncommon cause of cardiac arrest in young individuals with no structural heart disease. The genetic substrate of this condition is heterogeneous and remains incompletely defined. We describe a case of short-coupled premature ventricular complex-triggered ventricular fibrillation with a likely pathogenic variant in the titin () gene.

Switchable catalysis and CO sensing by reduction resistant, luminescent copper-thiolate complexes.

Metal-thiolate complexes have been the focus of research for several years because of their unique photophysical properties and their use as a precursor for synthesizing various well-defined metal nanoclusters. A rational understanding of their structure-property relationship is necessary to realize their full potential in practical applications. Herein, we demonstrate the synthesis of a unique copper-thiolate complex with reversibly switchable catalytic and photoluminescence (PL) properties.

Improving Lateral Resolution in 3-D Imaging With Micro-beamforming Through Adaptive Beamforming by Deep Learning.

There is an increased desire for miniature ultrasound probes with small apertures to provide volumetric images at high frame rates for in-body applications. Satisfying these increased requirements makes simultaneous achievement of a good lateral resolution a challenge. As micro-beamforming is often employed to reduce data rate and cable count to acceptable levels, receive processing methods that try to improve spatial resolution will have to compensate the introduced reduction in focusing.