Publications by authors named "Bequet C"
Background: "Biopsy-only" glioblastoma (BO-GBM) is a heterogeneous, understudied group of patients associated with a poor outcome. Our objective was to explore the pattern of care and prognosis associated with BO-GBM in our center.
Methods: Patients with wild-type BO-GBM included in a prospective regional cohort initiated in 2014 and closed in 2017 were retrospectively reviewed for patient characteristics, MRI findings, treatment allocation, and delivery.
Background: Immunity plays an important role in CNS-DLBCL development. CNS-DLBCL predictive factors need to be improved.
Objective: To evaluate the predictive value of circulating lymphocyte subsets in PCNSL patients.
Purpose: We aimed to identify genomic drivers of glioblastoma inevitable recurrence.
Methods: Ten pairs of initial and recurrent frozen IDHwt glioblastoma samples were screened by CGH Array. Next Generation Sequencing (NGS) was then performed on an enriched cohort of 19 pairs.
Article Synopsis
- Thalamic gliomas are rare brain tumors in adults that are hard to treat and understand.
- Researchers studied 38 adult patients to learn more about these tumors, including symptoms and survival rates.
- They found that younger patients with a specific gene mutation (H3K27M) had a better chance of living longer, unlike older patients who had more symptoms.
Glioblastoma is the most frequent and aggressive primary brain tumor in adults. Recently, a growing number of studies have shown that denaturation profile of plasma samples obtained by differential scanning calorimetry (DSC) can represent a signature of a disease. In this study, we analyzed for the first time the DSC denaturation profiles of the plasma from patients with recurrent glioblastoma (n=17).
View Article and Find Full Text PDFBackground: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade glioma that frequently occurs in pediatric patients.
Objective: To analyze adult patients diagnosed with PXA and to search for pathological and molecular markers of diagnosis and prognosis.
Methods: We retrospectively included patients older than 16 years with PXA who were referred to our institution between October 2003 and September 2013.
Background/aim: The drug combination of procarbazine, lomustine (CCNU) and vincristine (PCV) has been associated with efficacy in oligodendroglial gliomas (OG) when added to radiotherapy as the first line of treatment, despite the important toxicity of this treatment schedule. The aim of the present study was to analyze the tolerance, feasibility and impact of the dose intensity of the PCV regimen on outcome for patients with OG.
Patients And Methods: We retrospectively reviewed all patients with OG receiving PCV (CCNU=110 mg/m(2)) who were referred to our two Institutions.