Publications by authors named "Beom Seok Seo"

Article Synopsis
  • The study investigated the occurrence of cranial cruciate ligament rupture (RCCL) in small breed dogs and the role of tibial plateau angle (TPA) as a predictor for recovery.
  • It was found that neutered dogs, especially those neutered early, had a higher prevalence of RCCL, and that dogs with lower pre-operative TPA (≤25°) experienced faster recovery and fewer complications compared to those with higher TPA (>25°).
  • The findings suggest that maintaining a post-operative TPA of less than 10° is crucial for achieving favorable clinical outcomes following surgery.
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Article Synopsis
  • The B7-H3 protein, linked to poor clinical outcomes in various cancers, is a target for new cancer treatments due to its high expression in tumors and limited presence in normal tissues.
  • The study introduces ITC-6102RO, an innovative antibody-drug conjugate designed to selectively deliver a cytotoxic agent to B7-H3-overexpressing cancer cells, demonstrating effectiveness in both cell lines and xenograft models.
  • Results showed that ITC-6102RO reduces cell viability by inducing cell cycle arrest, DNA damage, and apoptosis in cancer cells, indicating its potential as a therapeutic option for B7-H3-targeted therapy.
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Purpose: To evaluate the effectiveness and safety of transarterial embolization (TAE) for chronic Achilles tendinopathy (AT) refractory to conservative treatment.

Materials And Methods: This retrospective study included 20 patients (12 men and 8 women; mean age, 30.3 years) who received TAE using imipenem/cilastatin sodium for refractory chronic AT from May 2019 to April 2021.

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Objective: In Korea, small dogs are more common than large breeds. This study was performed to measure the influence of body weight, sex, breed, age, and cranial cruciate ligament rupture (RCCL) on the tibial plateau angle (TPA) in small-breed dogs.

Materials And Methods: A total of 274 dogs (221 normal dogs and 53 RCCL dogs) were selected for this study based on medical records.

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Increased temperature means and fluctuations associated with climate change are predicted to exert profound effects on the seed yield of soybean. We conducted an experiment to evaluate the impacts of global warming on the phenology and yield of two determinate soybean cultivars in a temperate region (37.27°N, 126.

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Heat-killed Saccharomyces cerevisiae (HKSC) is an agonist for Dectin-1, a major fungal cell wall β-glucan receptor. We previously reported that HKSC selectively enhances IgG1 production by LPS-activated mouse B cells. To determine if this IgG1 selectivity is caused by selective IgG1 class switching, we performed RT-PCRs for measuring germline transcripts (GLTs), flow cytometric analyses for detecting Ig-expressing cells, and ELISPOT assays for measuring the number of Ig-secreting cells in HKSC/LPS-stimulated mouse B cell cultures.

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Dectin-1, which specifically recognizes β-glucan of fungal cell walls, is a non-Toll-like receptor (TLR) pattern recognition receptor and a representative of C-type lectin receptors (CLRs). The importance of Dectin-1 in innate immune cells, such as dendritic cells and macrophages, has previously been well studied. However, the function of Dectin-1 in B cells is very poorly understood.

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Objective: To determine the predictors affecting treatment outcome after application of the mandibular advancement device (MAD).

Design: Retrospective analysis.

Setting: Tertiary care university hospital.

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Objectives: Treating olfactory dysfunction is a challenge for physicians. One of the therapeutic options could be transplantation of stem cells. In this study, neural stem cells were transplanted into anosmic mice.

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Study Objectives: To evaluate the value of mouth opening during sleep for predicting surgical outcomes after uvulopalatopharyngoplasty (UPPP).

Methods: Retrospectively, 69 out of 120 consecutive patients with obstructive sleep apnea who underwent uvulopalatopharyngoplasty at an academic tertiary referral center were included in this study. Sixty-nine subjects underwent cephalometry, nocturnal polysomnography and sleep videofluoroscopy before and after UPPP.

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Objective: To analyze the efficacy of treating postviral olfactory loss with glucocorticoids, Ginkgo biloba, and mometasone furoate nasal spray.

Design: Randomized trial.

Setting: Academic research.

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Objective: To quantitatively evaluate the effects of the mandibular advancement device (MAD) on changes in the upper respiratory tract during sleep using sleep videofluoroscopy (SVF) in patients with obstructive sleep apnea (OSA).

Design: Retrospective analysis.

Setting: Academic tertiary referral center.

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Objectives: To evaluate retrospectively the efficacy of the mandibular advancement device (MAD) in Korean patients with obstructive sleep apnea (OSA) in terms of severity and to evaluate prognostic factors deciding the success of MAD application.

Design: Retrospective analysis.

Setting: Academic tertiary referral center.

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Objective: To evaluate the efficacy of intratympanic (IT) dexamethasone injection as a salvage treatment in idiopathic sudden hearing loss (ISHL) patients.

Design: A prospective study.

Setting: A secondary care hospital.

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Starch-branching enzymes (SBEs) catalyze the formation of alpha(1-->6) glycoside bonds in glucan polymers, thus, affecting the structure of amylopectin and starch granules. Two distinct classes of SBE are generally conserved in higher plants, although the specific role(s) of each isoform in determination of starch structure is not clearly understood. This study used a heterologous in vivo system to isolate the function of each of the three known SBE isoforms of maize (Zea mays) away from the other plant enzymes involved in starch biosynthesis.

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