Publications by authors named "Beom Seok Park"
Article Synopsis
- * This study reveals a connection between cellular senescence and increased infectivity of Kaposi's sarcoma-associated herpesvirus (KSHV) in endothelial cells, identifying caveolin-1 and CD109 as key factors that enhance KSHV infection.
- * Using CRISPR technology, researchers found that knocking out these factors reduces KSHV's ability to infect cells, while CD109 actively interacts with the virus and can inhibit its entry, highlighting the role of aging in viral infections.
Ovastacin: An oolemma protein that cleaves the zona pellucida to prevent polyspermy.
Clin Exp Reprod Med
September 2023
Article Synopsis
- * During fertilization, the sperm triggers an acrosomal reaction, releasing enzymes like ovastacin that help dissolve the ZP for successful egg penetration.
- * Ovastacin also prevents polyspermy by quickly degrading the ZP after the first sperm enters, blocking additional sperm from fertilizing the egg.
Article Synopsis
- Hybridization and polyploidization are key processes in plant evolution, but overcoming natural reproductive barriers for genetic crosses is not well understood.
- This study focuses on the synthetic allotetraploid plant xBrassicoraphanus, formed from Brassica rapa and Raphanus sativus, to explore its hybrid genome structure, chromosome behavior, and gene expression dynamics.
- Findings indicate that xBrassicoraphanus maintains both parental chromosomes without rearrangement, shows reconfiguration of gene expression networks, and demonstrates transcriptional silencing of certain transposable elements, highlighting the role of epigenetic changes in hybrid stability and compatibility.
Decorin: a multifunctional proteoglycan involved in oocyte maturation and trophoblast migration.
Clin Exp Reprod Med
December 2021
Article Synopsis
- - Decorin (DCN) is a vital proteoglycan involved in building and maintaining connective tissue, playing a key role in the extracellular matrix (ECM) assembly and interacting with various proteins like collagen and growth factors.
- - Normal DCN levels help regulate essential cellular functions such as cell growth, movement, and death; however, abnormal DCN expression can lead to complications in reproductive processes, including preeclampsia and poor embryo quality.
- - The review highlights DCN's significant role in the regulation of oocyte maturation and trophoblast migration during pregnancy, suggesting that recombinant DCN proteins could be beneficial for research on fertility and implantation processes.
Article Synopsis
- - Atopic dermatitis (AD) is a chronic skin condition characterized by inflammation and itchiness, with house dust mites, specifically Der p 38, identified as significant allergens that intensify its development.
- - In laboratory studies, Der p 38 was found to compromise filaggrin production, a key protein for skin barrier function, while promoting inflammation through various cellular pathways.
- - Experiments in mice showed that exposure to Der p 38 increased skin lesions and inflammatory cell activity, but these effects were less pronounced in mice lacking the TLR4 receptor, suggesting TLR4's crucial role in the allergenic response triggered by Der p 38.
Article Synopsis
- * Researchers utilized advanced techniques like mass spectrometry and biolayer interferometry to confirm Der p 38's allergenic properties and its direct activation of TLR4, leading to immune responses observed in allergic subjects.
- * Animal experiments demonstrated that Der p 38 administration caused symptoms resembling asthma and increased inflammation in allergy-related immune cells, highlighting its significant role in bridging different types of inflammation in allergic reactions.
Article Synopsis
- The study focuses on understanding a new allergen, Der f 38, which binds to the Toll-like receptor 4 (TLR4) and its role in allergic diseases like asthma.
- Research showed that Der f 38 is present in house dust mites and can trigger immune responses, leading to increased inflammation and allergic reactions in mice.
- Der f 38 also appears to influence cell survival by affecting apoptotic pathways, potentially contributing to the persistence of allergic reactions in individuals.
S100A8 and S100A9 are important proteins in the pathogenesis of allergy. Asthma is an allergic lung disease, characterized by bronchial inflammation due to leukocytes, bronchoconstriction, and allergen-specific IgE. In this study, we examined the role of S100A8 and S100A9 in the interaction of cytokine release from bronchial epithelial cells, with constitutive apoptosis of neutrophils.
View Article and Find Full Text PDFArticle Synopsis
- The text refers to a correction made to a previously published article in a scientific journal.
- The article in question has a Digital Object Identifier (DOI) of 10.3389/fmicb.2018.01466.
- The correction aims to address and clarify some aspects of the original research findings.
Article Synopsis
- - The study aimed to identify the educational needs for job competence among physical therapist assistant students at Quang Tri Medical College in Vietnam.
- - Participants, through self-assessment questionnaires, ranked "system checkup" as the most important job competence, while "cooperation, communication, and documentation" were recognized as their strongest current competencies.
- - The study concluded that "counseling and education" ranked highest in educational needs, emphasizing its importance for effective healthcare and suggesting it should be prioritized in the curriculum.
Article Synopsis
- Norovirus (NoV) is a major cause of viral gastroenteritis, and its replication involves the interaction between viral proteins VPg and RNA-dependent RNA polymerase (RdRp).
- In this study, VPg from murine NoV was shown to enhance the activity of RdRp by forming higher-order multimers or fibrils, which is crucial for effective replication.
- The research suggests that targeting the interaction between VPg and RdRp could be a potential strategy for treating NoV outbreaks.
Hibiscus syriacus (L.) (rose of Sharon) is one of the most widespread garden shrubs in the world. We report a draft of the H.
View Article and Find Full Text PDFLipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, binds Toll-like receptor 4 (TLR4)-MD2 complex and activates innate immune responses. LPS transfer to TLR4-MD2 is catalyzed by both LPS binding protein (LBP) and CD14. To define the sequential molecular interactions underlying this transfer, we reconstituted in vitro the entire LPS transfer process from LPS micelles to TLR4-MD2.
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- Dysregulation of neutrophil apoptosis, influenced by the protein S100A9, plays a role in the development and worsening of allergies by affecting immune responses.
- The study showed that S100A9 inhibits neutrophil apoptosis by activating monocytes and increasing the release of inflammation-related cytokines MCP-1, IL-6, and IL-8 when exposed to normal and allergic conditions.
- Multiple inhibitors impacted the signaling pathways activated by S100A9, including TLR4 and various kinases, highlighting how S100A9 mediates anti-apoptotic effects through increased cytokine secretion in both normal and allergic subjects.
Article Synopsis
- * Researchers performed whole-genome resequencing of 17 radish accessions (10 cultivated and 7 wild) and found 4 million high-quality SNPs, revealing that Asian cultivated radishes are closely related to their wild counterparts, highlighting unique domestication pathways compared to European/American radishes.
- * The analysis identified 153 candidate domestication regions with genes linked to root development, signaling pathways, and metabolism, suggesting that traits like a main taproot and better taste resulted from selective breeding in radishes
Background: Rice germplasm collections continue to grow in number and size around the world. Since maintaining and screening such massive resources remains challenging, it is important to establish practical methods to manage them. A core collection, by definition, refers to a subset of the entire population that preserves the majority of genetic diversity, enhancing the efficiency of germplasm utilization.
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- This study presents the first chromosome-scale draft genome sequence of radish, revealing it is organized into nine chromosomal pseudomolecules and covers over 98% of the gene space.
- A comparative analysis with Brassica genomes shows that the radish genome evolved from a hexaploid ancestor and displays traits from both the A/C and B genomes.
- The findings highlight radish's evolutionary background and contribute to the understanding of mesohexaploid genomes in the Brassiceae tribe.
Article Synopsis
- - Glucosinolates (GSLs) are beneficial compounds in Brassicaceae plants, helping prevent cancer and defending against pests, with the MYB28 transcription factor playing a key role in their production.
- - Brassicaceae plants possess three similar copies of the MYB28 gene, and when these genes were overexpressed in Chinese cabbage, it significantly boosted GSL levels, particularly in certain T2 homozygous lines.
- - The study revealed differences in GSL biosynthesis regulation between B. rapa and A. thaliana, highlighting the unique mechanisms at play in polyploid plants and offering insights for further research.
Article Synopsis
- Cytoplasmic chloroplast genomes and nuclear ribosomal DNA are crucial for studying plant diversity and evolution, particularly in rice.
- A new high-throughput method utilizing Illumina sequencing was developed to obtain complete sequences of both cp and nR from 30 rice specimens across nine Oryza species.
- The research revealed insights into rice evolution and domestication, highlighting biases in cp-based classifications, the hybridization of wild rice species, and the identification of perennial traits in certain Australian rice varieties.
Genomic Survey and Biochemical Analysis of Recombinant Candidate Cyanobacteriochromes Reveals Enrichment for Near UV/Violet Sensors in the Halotolerant and Alkaliphilic Cyanobacterium Microcoleus IPPAS B353.
J Biol Chem
November 2015
Article Synopsis
- Cyanobacteriochromes (CBCRs) are specialized photoproteins in cyanobacteria that can sense a range of near-UV and visible light, showing a connection to plant phytochromes.
- This study focused on the genome sequencing of Microcoleus B353, a mat-forming cyanobacterium, revealing two phytochromes and seven CBCRs, along with various GAF domain proteins that interact with bilin chromophores.
- The findings indicate that Microcoleus B353 has a unique set of CBCRs, primarily tuned to detect near-UV and violet light, which may help it adapt to high-light environments where it thrives.
Cultivated soybean (Glycine max) suffers from a narrow germplasm relative to other crop species, probably because of under-use of wild soybean (Glycine soja) as a breeding resource. Use of a single nucleotide polymorphism (SNP) genotyping array is a promising method for dissecting cultivated and wild germplasms to identify important adaptive genes through high-density genetic mapping and genome-wide association studies. Here we describe a large soybean SNP array for use in diversity analyses, linkage mapping and genome-wide association analyses.
View Article and Find Full Text PDFAdzuki bean (Vigna angularis var. angularis) is a dietary legume crop in East Asia. The presumed progenitor (Vigna angularis var.
View Article and Find Full Text PDFThis manuscript provides a genetic map of Raphanus sativus that has been used as a reference genetic map for an ongoing genome sequencing project. The map was constructed based on genotyping by whole-genome resequencing of mapping parents and F 2 population. Raphanus sativus is an annual vegetable crop species of the Brassicaceae family and is one of the key plants in the seed industry, especially in East Asia.
View Article and Find Full Text PDFSynaptic adhesion molecules orchestrate synaptogenesis. The presynaptic leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) regulate synapse development by interacting with postsynaptic Slit- and Trk-like family proteins (Slitrks), which harbour two extracellular leucine-rich repeats (LRR1 and LRR2). Here we identify the minimal regions of the LAR-RPTPs and Slitrks, LAR-RPTPs Ig1-3 and Slitrks LRR1, for their interaction and synaptogenic function.
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- Mungbean (Vigna radiata) is a fast-growing legume mostly cultivated in developing Asian countries, and researchers have created a draft genome sequence for it to advance genetic studies in related legumes.
- The study indicates that the domesticated mungbean diverged from its wild relatives before domestication, indicating a complex evolutionary history.
- Additionally, the discovery of genomic evidence from a tetraploid Vigna species reveals recent allopolyploid events, and the construction of a species tree helps improve understanding of the genetic relationships among various Vigna species.