Pheophorbide co-encapsulated with Cisplatin in folate-decorated PLGA nanoparticles to treat nasopharyngeal carcinoma: Combination of chemotherapy and photodynamic therapy.

The adverse effect and drug resistance of Cisplatin (CDDP) could be potential reduced by delivering in targeted nanoparticles and by combining with adjuvant therapy such as photodynamic therapy. In this study, F/CDPR-NP was formulated and characterized for all the physicochemical, biological and in vivo analysis. The results obtained from various in vitro and biological studies showed that encapsulation of CDDP and PBR in PLGA nanoparticles results in controlled release of encapsulated drugs and exhibited significantly low cell viability in CNE-1 and HNE-1 cancer cells.

Large lipoma in the subglottic larynx: a case report.

Lipomas are rare benign tumors in the larynx. We encountered a 70-year-old man with a large lipoma in the subglottic area. His chief symptom was a 3-month history of progressive dyspnea.

[Changes of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome before and after treatment of surgery].

Objective: To investigate the change of serum leptin levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after surgery.

Method: The cases were divided into effective (n=44) and non-effective (n=13) groups according to PSG. The effective cases were divided into decreased (> or = 5%, n=25) and non-decreased(<5%, n=19) BMI.

[Evaluation of the medical and surgical treatment of pediatric chronic rhinosinusitis].

Objective: To compare the effect of the medical and surgical treatment of pediatric chronic rhinosinusitis (CRS).

Method: Seventy-two cases of pediatric CRS were randomly divided into medical group (35 cases) and surgical group (37 cases). The patients in medical group received a 12-week course of clarithromycin, alkaline nasal douche and intranasal mometasone furoate.

[A study of the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome and obesity and patients with normal body mass].

Objective: To explore the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and obesity and patients with normal body mass.

Method: Polysomnography (PSG) was performed in 53 patients with OSAHS and in 41 simple obesity and in 62 patients with normal body mass. The level of serum leptin was detected by radioimmunoassay.

[Clinical study on oropharyngeal fatty infiltration on the pathogenesis of obstructive sleep apnea syndrome].

Objective: To detect the effect of lipid metabolism, fatty infiltration of oropharyngeal tissues in the subjects with obstructive sleep apnea syndrome (OSAS) and its pathogenesis.

Method: Nineteen subjects in OSAS group and 9 subjects in controlled group were chosen. The related clinical index including the size and weight of uvula in two groups were measured.