Publications by authors named "Benyan Luo"

Background: Sleep is essential for the recovery of patients with disorders of consciousness (DoC). However, few approaches targeting sleep were applied. Melatonin has been shown to enhance sleep efficiency with virtually no side effects.

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  • The study investigates how aging leads to degeneration of the neuromuscular junction (NMJ) and decreased motor function, focusing on the protein Sirt6 in aged mouse muscles.
  • Researchers found that lower levels of Sirt6 result in decreased Dystrophin, causing faster NMJ degeneration and poorer motor performance by affecting protein stability.
  • Supplementing with nicotinamide mononucleotide (NMN) boosts the positive effects of Sirt6, helping to delay NMJ degeneration and maintain motor function in older mice, suggesting a promising therapeutic strategy.
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  • * Findings revealed a significant increase in these microglial EVs in patients with multiple sclerosis (MS) and especially high levels in those with HTLV-1 associated myelopathy (HAM), while Alzheimer's disease (AD) and Parkinson's disease (PD) showed no change or decreased levels.
  • * The research suggests that the combination of CX3CR1/UCHL1, NMDAR2A, and NFL EVs has strong potential as a diagnostic tool for differentiating MS from other
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Detecting consciousness in clinically unresponsive patients remains a significant challenge. Existing studies demonstrate that electroencephalography (EEG) can detect brain responses in behaviorally unresponsive patients, indicating potential for consciousness detection. However, most of this evidence is based on chronic patients, and there is a lack of studies focusing on acute coma cases.

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Background: To evaluate the feasibility, success rate, and safety of endovascular revascularization of patients with vertebral artery stump syndrome (VASS).

Methods: This single-center retrospective study analyzed clinical and imaging data from consecutive patients with VASS who underwent endovascular recanalization from January 2020 until June 2023.

Results: Our study enrolled 30 patients [mean age 69 (range 51-84) years; 26 men].

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  • Diagnosing patients who are not fully conscious is hard and can be incorrect, but using EEG, which records brain activity, helps a lot.
  • The new system called DOCTer uses EEG signals and patient information to tell the difference between two states: minimally conscious and unresponsive wakefulness.
  • With a big dataset of EEG recordings, DOCTer has shown to be really effective in finding the right diagnosis, which can help doctors create better treatment plans for patients.
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  • Motor neurons are specialized cells that send signals over long distances to connect with muscles through neuromuscular junctions (NMJs), but local translation of proteins at these junctions hasn't been fully understood.
  • Recent research using advanced techniques identified that specific mRNAs linked to energy production and synaptic function are localized and translated at NMJs, which change focus from building structures in development to energy production in adulthood.
  • The study highlights the importance of the mRNA encoding Agrin at motor axon terminals; disrupting its local translation negatively affects motor function and synaptic transmission, implying that precise regulation at NMJs is crucial for proper muscle control.
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  • *In-stent restenosis (ISR) can obstruct blood flow and lead to serious issues like stroke, primarily due to endothelial cell growth and thrombosis, yet metabolic changes in this process are poorly understood.*
  • *The study aimed to analyze the serum metabolome of patients with ISR versus those without restenosis using metabolomics and lipidomics, focusing on key metabolic pathways.*
  • *Results indicated significant metabolic changes in the cysteine and methionine pathways in ISR patients, including increased levels of certain metabolites and lipids, suggesting active lipid metabolism may contribute to blood clot recurrence, with phenol sulfate and PS(38:4) identified as potential biomarkers for ISR.*
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  • The subcommissural organ (SCO) is a brain gland whose function remains largely unclear, despite being present in a variety of species, including humans.
  • A comparison of gene expression in the SCO versus non-SCO brain areas revealed three key genes (Sspo, Car3, and Spdef) that are highly active in the SCO.
  • Genetic removal of SCO cells during embryonic development led to significant brain issues like hydrocephalus and impaired neuron growth, but introducing certain peptides from the SCO helped to alleviate these developmental problems.
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Background: Plasma amyloid-β (Aβ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) potentially aid in the diagnosis of neurodegenerative dementias. We aim to conduct a comprehensive comparison between different biomarkers and their combination, which is lacking, in a multicenter Chinese dementia cohort consisting of Alzheimer's disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP).

Methods: We enrolled 92 demented patients [64 AD, 16 FTD, and 12 PSP with dementia] and 20 healthy controls (HC).

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  • The subcommissural organ (SCO) is a brain gland found in various species, but its specific functions remain largely unclear.
  • Research identified three genes that are significantly active in the SCO and showed that disrupting these genes in mice led to severe brain issues, including hydrocephalus and neuronal development problems.
  • The study also discovered three peptides produced by the SCO that, when reintroduced into affected brain areas, helped mitigate developmental defects, highlighting the SCO's essential role in brain development.
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The assessment of consciousness states, especially distinguishing minimally conscious states (MCS) from unresponsive wakefulness states (UWS), constitutes a pivotal role in clinical therapies. Despite that numerous neural signatures of consciousness have been proposed, the effectiveness and reliability of such signatures for clinical consciousness assessment still remains an intense debate. Through a comprehensive review of the literature, inconsistent findings are observed about the effectiveness of diverse neural signatures.

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Major Depression Disorder (MDD) is a common yet destructive mental disorder that affects millions of people worldwide. Making early and accurate diagnosis of it is very meaningful. Recently, EEG, a non-invasive technique of recording spontaneous electrical activity of brains, has been widely used for MDD diagnosis.

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The roles of cerebral structures distal to isolated thalamic infarcts in cognitive deficits remain unclear. We aimed to identify the in vivo microstructural characteristics of remote gray matter (GM) and thalamic pathways and elucidate their roles across cognitive domains. Patients with isolated ischemic thalamic stroke and healthy controls underwent neuropsychological assessment and magnetic resonance imaging.

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Alzheimer's disease (AD) is the most prevalent form of dementia among elderly people worldwide. Cerebrospinal fluid (CSF) is the optimal fluid source for AD biomarkers, while serum biomarkers are much more achievable. To search for novel diagnostic AD biomarkers, we performed a quantitative proteomic analysis of CSF and serum samples from AD and normal cognitive controls (NC).

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Aims: The electroencephalography (EEG) microstates are indicative of fundamental information processing mechanisms, which are severely damaged in patients with prolonged disorders of consciousness (pDoC). We aimed to improve the topographic analysis of EEG microstates and explore indicators available for diagnosis and prognosis prediction of patients with pDoC, which were still lacking.

Methods: We conducted EEG recordings on 59 patients with pDoC and 32 healthy controls.

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Aim: Disruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic-electric trigeminal-nerve stimulation (i.e.

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When listening to speech, the low-frequency cortical response below 10 Hz can track the speech envelope. Previous studies have demonstrated that the phase lag between speech envelope and cortical response can reflect the mechanism by which the envelope-tracking response is generated. Here, we analyze whether the mechanism to generate the envelope-tracking response is modulated by the level of consciousness, by studying how the stimulus-response phase lag is modulated by the disorder of consciousness (DoC).

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Objective: This study aimed to assess the prognosis of patients with disorders of consciousness (DoC) using auditory stimulation with electroencephalogram (EEG) recordings.

Methods: We enrolled 72 patients with DoC in the study, which involved subjecting patients to auditory stimulation while EEG responses were recorded. Coma Recovery Scale-Revised (CRS-R) scores and Glasgow Outcome Scale (GOS) were determined for each patient and followed up for three months.

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Background: The aim of this study is to assess the central auditory processing (CAP) function and its electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) and the early stage of Alzheimer's disease (AD).

Methods: In this study, 25 patients with early AD, 22 patients with MCI, and 22 matched healthy controls (HC) were included. After cognitive assessment, binaural processing function was assessed using the staggered spondaic word (SSW) test, and auditory working memory was assessed by auditory n-back paradigm, while EEG was recorded.

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Consciousness detection is important in diagnosis and treatment of disorders of consciousness (DOC). Recent studies have demonstrated that electroencephalography (EEG) signals contain effective information for consciousness state evaluation. We propose two novel EEG measures: the spatiotemporal correntropy and the neuromodulation intensity, to reflect the temporal-spatial complexity in brain signals for consciousness detection.

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Importance: Stroke is the leading cause of death in China. However, recent data about the up-to-date stroke burden in China are limited.

Objective: To investigate the urban-rural disparity of stroke burden in the Chinese adult population, including prevalence, incidence, and mortality rate, and disparities between urban and rural populations.

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Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form of dipeptide repeat proteins (DPRs) produced from GGGGCC repeats, tends to form neurotoxic protein aggregates. The C9orf72 GGGGCC repeats and microglial receptor TREM2 are both associated with risk for ALS/FTD.

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Spinal cord injury is a serious injury of the central nervous system that results in neurological deficits. The pathophysiological mechanisms underlying spinal cord injury, as well as the mechanisms involved in neural repair and regeneration, are highly complex. Although there have been many studies on these mechanisms, there is no effective intervention for such injury.

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Objective: Alzheimer's disease (AD) is the most prevalent form of dementia among the aging population. Cumulative studies aim to find non-invasive biomarkers in the early stages of AD. Saliva can be obtained easily, and salivary biomarkers have been proven effective in detecting neurodegenerative diseases.

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