Clinical Manifestations.

Background: Although there is evidence that measures of verbal fluency, naming and word memory can be good predictors of progression to dementia, language change and the main variables predicting it are not yet fully characterized. Recent research draws attention to the need to consider cognitive reserve, functional, and neurobiological indicators together to explain changes (Facal et al., 2021).

Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes.

Functional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer's disease, have generated contradictory results in terms of compensation and deterioration, as most of the studies did not distinguish between the different aMCI subtypes: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The present study aimed to characterize the neurophysiological correlates of aMCI subtypes by using resting-state functional magnetic resonance imaging. The study included sd-aMCI (n = 29), md-aMCI (n = 26), and control (n = 30) participants.

Combined anodal transcranial direct current stimulation and behavioural naming treatment improves language performance in patients with post-stroke aphasia.

Primary Objective: During the last decade, studies using anodal transcranial Direct Current Stimulation (atDCS) have yielded promising results in patients with aphasia. The main aim of the present pilot study was to assess the effects of combined atDCS over the left posterior perisylvian region and behavioral naming training on the behavioral outcomes of language comprehension and production of patients with post-stroke aphasia.

Research Design: A 2 × 2 quasi-experimental design was conducted, optimal to compare changes after treatment in experimental versus control group.

Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging.

Cognitive Reserve (CR) is considered a protective factor during the aging process. However, although CR is a multifactorial construct, it has been operationalized in a unitary way (years of formal education or IQ). In the present study, a validated measure to categorize CR holistically (Cognitive Reserve Index Questionnaire) was used to evaluate the resting-state functional connectivity in 77 cognitively unimpaired participants aged 50 years and over with high and low CR, and matched brain global atrophy levels.