Publications by authors named "Bentolhoda Kuhestani Dehaghi"
Background: The progression of leukemia is substantially associated with the interactions of leukemic cells with surrounding cells within the bone marrow microenvironment (BMM), and these interactions were facilitated using exosomes as vital mediators. The current study aimed to examine the proliferative effects of exosomes derived from the HL-60 cell line, a representative of acute myeloblastic leukemia (AML), on the cell cycle progression of human bone marrow mesenchymal stromal cells (hBM-MSCs), a key element of the BMM.
Methods And Results: hBM-MSCs were treated with different concentrations of AML-derived exosomes from the HL-60 cell line.
Article Synopsis
- The study examines the role of exosomes from Acute Myeloid Leukemia (AML) cells in altering the bone marrow microenvironment, which can contribute to therapy resistance and relapse in AML patients.
- Researchers isolated and characterized AML exosomes and treated human bone marrow mesenchymal stromal cells (h BM-MSCs) with these exosomes to analyze their effects on cell viability and gene expression related to the JAK/STAT signaling pathway.
- Results indicated that AML exosomes promoted the survival of MSCs and significantly increased the expression of JAK2, STAT3, and STAT5 genes, suggesting that this may support leukemia cell proliferation and lead to chemoresistance.
Article Synopsis
- The rise of cancer cases, including leukemia, highlights challenges such as drug resistance and chemotherapy complications; extracellular vesicles (EV), particularly exosomes, show promise in cancer management.
- Exosomes extracted from NALM6 cells were verified using various methods, revealing they contained specific markers and had an average size of 89.68 nm with a protein content of 956.292 µg/ml.
- Results indicated that at a dose of 50 µg/ml, exosomes significantly increased the proliferation of mesenchymal stem cells (MSCs), suggesting they may enhance drug resistance and contribute to high mortality in acute lymphoblastic leukemia.
Introduction: B cell acute lymphoblastic leukemia-lymphoma (B-ALL) accounts for approximately 75% of ALL cases and is observed in children and adults. Recent advances in disease diagnosis, stratification and prognostication have led to a better characterization of different subgroups of ALL. Notwithstanding the significant improvement in the complete remission rate of B-ALL, patients with minimal residual disease (MRD) and relapsed/refractory (R/R) settings suffer from poor outcomes.
View Article and Find Full Text PDFBackground: Several reports have associated the severe Coronavirus disease-2019 (sCOVID-19) with secondary-hemophagocytic lymphohistiocytosis (sHLH) and proposed utilizing the hemophagocytic syndrome diagnostic score (HScore) for sCOVID-19 patients. We conducted a systematic review and meta-analysis to find the possible association of HScore parameters with severity in COVID-19 patients.
Methods: A systematic search was performed in Medline via PubMed, EMBASE, and Cochrane databases using all HScore and COVID-19 keywords.
Hematopoietic stem cell transplantation (HSCT) is a curative option for various hematologic malignancies. However, fatal complications, such as relapse and graft-versus-host disease (GVHD) hampered favorable HSCT outcomes. Cancer cells remained in the body following the conditioning regimen, or those contaminating the autologous graft can cause relapse.
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