Visual acuity and anterior segment findings in chronic graft-versus-host disease.

Purpose: To report risk factors for decreased visual acuity in patients with chronic graft-versus-host disease (cGVHD) diagnosed after hematopoietic cell transplantation (HCT) and to describe the prevalence of anterior segment findings in these patients.

Methods: Retrospective noncomparative study of 429 consecutive patients with cGVHD. Outcome measures include visual acuity, Schirmer scores, and ocular surface abnormalities.

Cataracts after bone marrow transplantation: long-term follow-up of adults treated with fractionated total body irradiation.

Purpose: To determine the risk of, and risk factors for, developing cataracts after bone marrow transplantation.

Methods And Materials: Four hundred and ninety-two adults who underwent bone marrow transplantation in Seattle were followed for 2 to 18 (median, 6) years. Before transplantation, patients received a preparative regimen of chemotherapy plus total body irradiation (TBI) (n = 407) or chemotherapy alone, without TBI (n = 85).

Glaucoma. A general perspective.

Glaucoma is the most prevalent disease ophthalmologists deal with. It affects the elderly more commonly and has a higher incidence in blacks. This review covers basic precepts of the disease including tips to help the general physician identify suspect cases.

Color vision testing.

1. Color deficiency occurs in about 8% of the population, due to alterations in the chemistry of one of the three receptive pigments for colored light, or the substitution of one pigment for another in the photoreceptor cones. 2.

Optic nerve head axonal transport in rabbits with hereditary glaucoma.

Rabbits with hereditary glaucoma develop ocular changes that resemble human congenital glaucoma and buphthalmia. The inheritance is autosomal recessive (bu). Previous research was performed primarily on albino bu/bu rabbits that were unhealthy and bred poorly.

Breakdown of the outer blood-retinal barrier in experimental commotio retinae.

An animal model has been developed in this study to produce commotio retinae (Berlin's edema) by means of standardized, non-penetrating B.B. pistol injury to the cornea.

Levobunolol. A three-month efficacy study in the treatment of glaucoma and ocular hypertension.

The ocular hypotensive effect and the safety of levobunolol hydrochloride (0.5% and 1%) were compared with vehicle in this double-masked study of 42 patients with chronic open-angle glaucoma or ocular hypertension. After a washout of ocular hypotensive medication, patients received one of the three test treatments in both eyes twice daily for three months.

Metaphors of glaucoma.

In a phenomenological study of glaucoma as an illness, 31 patients were interviewed. The goal of the study was an explication of the meanings of the experience of glaucoma, in a twofold sense: (1) the face, the role, or the self of the patient that responds to the illness; (2) the visage that the illness presents to the patient. This twofold explication was achieved by generating a classification of the interviews in terms of the dominant metaphor that emerged in each interview.

Thirty-year history of sympathetic ophthalmia.

A spontaneous corneal perforation followed by granulomatous uveitis occurred in a 10-month-old female infant with bilateral anterior segment anomalies. The histopathologic findings in the enucleated right eye and the 30-year course of intraocular inflammation in her left eye are consistent with sympathetic ophthalmia. This case illustrates that sympathetic ophthalmia can be overlooked for years unless the diagnosis is considered and periodic anterior segment biomicroscopy and indirect ophthalmoscopy are performed in patients who have had perforating ocular injuries.

Bilateral subconjunctival hemorrhage after acetylsalicylic acid overdose.

Isolated bilateral subconjunctival hemorrhages developed in an adult patient after ingestion of a large amount (6.48 g) of aspirin. The time course and bilateral pattern suggest a direct metabolic relationship between these two events.

Resorbable implant for orbital defects.

Tricalcium phosphate ceramic, a synthetic bone substitute, was inserted into defects created in the inferior orbital rims of 18 rabbits. The animals were killed after three, eight, 24, and 40 weeks. Early sections demonstrated encapsulation with fibrous ingrowth.

Bronchocentric granulomatosis with eye involvement.

Bronchocentric granulomatosis is a recently defined entity within the "pulmonary angitis and granulomatosis" group of lung diseases. Unlike the other granulomatoses, extrapulmonary disease has not been encountered with bronchocentric granulomatosis. Therefore, we report a case demonstrating apparent association with scleritis, an uncommon eye disorder often accompanying underlying systemic disease.

Alveolar soft-part sarcoma of the orbit.

An 11-month-old white female with a three-month history of swelling of soft tissue around the right eye presented with a proptotic globe and marked limitation of motility. A CT scan showed a soft-tissue mass in the orbit, which was biopsied and examined by light and electron microscopy. The specimen consisted of large polygonal and cuboidal cells of uniform appearance arranged in pseudo-alveoli around capillaries.

Pilocarpine ocular inserts.

Pilocarpine was administered to a selected group of ocular hypertensive subjects in the form of a synthetic biosoluble matrix inserted into the conjunctival cul-de-sac. Satisfactory lowering of the intraocular pressure resulted, with a minimum of subject intolerance. The decreased pressure response was significant in some cases for greater than 24 hours.

Studies on the differentiation of retinal pigmented epithelium cells in culture.

Sephadex G-25 fractions of chick embryo extract affect the differentiation of cloned embryonic pigmented epithelial cells (PE) in culture. Both tyrosinase activity and amounts of melanin are markedly affected by the extract fractions. 5-Hydroxyindole decreased melanin accumulation in PE cells while alpha-methyl-p-tyrosine had no apparent effect on the process.