Rarity of congenital adrenal hyperplasia in children born very preterm:Possible mechanism and implication for newborn screening.

Introduction: Screening for congenital adrenal hyperplasia through the measurement of 17-hydroxyprogesterone on the neonatal blood spot aims to: a) prevent neonatal deaths; b) allow earlier identification and thereby decrease the severity of the initial salt-wasting episode; and c) shorten the time during which a severely virilized genetic female newborn may be assigned the male sex. It is now practiced in the majority of high-income countries, although the positive predictive value of the test is very low in infants born preterm, who seem to be infrequently affected. In almost all low- and middle-income countries, it has not yet been implemented.

Acute lower limb ischemia revealing hypo granular acute promyelocytic leukemia.

Introduction: Acute promyelocytic leukemia (AML-M3), classified as acute Myeloid leukemia with PML RARA according to the 5th edition of the World Health Organization classification of haematolymphoid tumors 2022 [1], is marked by abnormal promyelocyte proliferation and is known for high risks of bleeding and thromboembolic complications. We present a case where lower limb ischemia revealed this leukemia in a child.

Case Report: An 11-year-old with minor ankle trauma developed severe lower limb ischemia, leading to the discovery of subtotal femoral artery thrombosis.

Comparative Study of Cerebrospinal Fluid Evaluation in Patients With Acute Leukemia Using the Manual Method and Sysmex XN-1000.

Background Many pathological settings can be provided by the cytological analysis of cerebrospinal fluid (CSF). In our work, we aimed to evaluate the concordance between the analysis using the reference manual method and the analysis using Sysmex XN-1000. Methods In our study, we examined 121 CSF samples.

Comparison of two deep-learning image reconstruction algorithms on cardiac CT images: A phantom study.

Purpose: The purpose of this study was to compare the performance of Precise IQ Engine (PIQE) and Advanced intelligent Clear-IQ Engine (AiCE) algorithms on image-quality according to the dose level in a cardiac computed tomography (CT) protocol.

Materials And Methods: Acquisitions were performed using the CT ACR 464 phantom at three dose levels (volume CT dose indexes: 7.1/5.

Hydatid cyst in the parotid gland, a rare localization of the disease: A case report.

Introduction And Importance: Hydatid cysts are often found in the liver or lungs. As for the parotid localization, it remains exceptional even in endemic areas and presents as a tumor of the parotid thus representing a challenge to the practitioner.

Case Presentation: A 54-year-old male farmer presented with a swelling in the left parotid gland region evolving over the past 2 years.

Development of shelf life-extending packaging for vitamin C syrup based on high-density polyethylene and extracted lignin argan shells.

Biobased packaging is an essential parameter in the pharmaceutical industry. In the present work, bio-composites consisting of high-density polyethylene (HDPE) as a matrix and lignin recovered from argan nut shells as filler were developed to investigate their potential use as packaging materials for vitamin C drugs. The lignin was extracted via alkali and klason processes, and the effects of the extraction method as well as the lignin content on the thermal, morphological, mechanical, and rheological properties of the produced composites, as well as their application for vitamin C packaging, were investigated.

Intestinal Candida albicans overgrowth in IgA deficiency.

Background: Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown.

Objectives: Our goal was to study the impact of IgA on gut mycobiota ecology.

Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.

Smart materials based on biomaterials have been shown growing interest by researchers. This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix. Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.

Update on anti-fibrotic pharmacotherapies in skeletal muscle disease.

Fibrosis, defined as an excessive accumulation of extracellular matrix, is the end point of a defective regenerative process, unresolved inflammation and/or chronic damage. Numerous muscle disorders (MD) are characterized by high levels of fibrosis associated with muscle wasting and weakness. Fibrosis alters muscle homeostasis/regeneration and fiber environment and may interfere with gene and cell therapies.

Hemiparesis Revealing a Unique Neurological Hemophagocytic Lymphohistiocytosis in a Patient With Griscelli Syndrome Type 2.

Griscelli syndrome (GS) is a rare genetic disorder that encompasses three different subtypes (GS type 1 (GS1), GS type 2 (GS2), and GS type 3 (GS3)), in which isolated neurological manifestations without immune system implications are typically seen in GS1, while neurological involvements in GS2 should be attributed to the macrophage and lymphocyte invasion of the central nervous system (CNS), under associated hemophagocytic lymphohistiocytosis (HLH). The presence of the clinical, biological, and hematologic features of HLH help explain the neurological defects that GS2 patients unusually present. In our case report, however, we attempt to highlight an uncommon presentation of GS2 involving a hemiparesis, along which we did not have any clinical or biological features of HLH.

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their "virtual" secretome.

Skeletal muscle is a highly plastic tissue composed of a number of heterogeneous cell populations that, by interacting and communicating with each other, participate to the muscle homeostasis, and orchestrate regeneration and repair in healthy and diseased conditions. Although muscle regeneration relies on the activity of muscle stem cells (MuSCs), many other cellular players such as inflammatory, vascular and tissue-resident mesenchymal cells participate and communicate with MuSCs to sustain the regenerative process. Among them, Fibro-Adipogenic Progenitors (FAPs), a muscle interstitial stromal population, are crucial actors during muscle homeostasis and regeneration, interacting with MuSCs and other cellular players and dynamically producing and remodelling the extra-cellular matrix.

Intelligent food packaging film containing lignin and cellulose nanocrystals for shelf life extension of food.

The UV-protection films based on renewable materials extracted from natural sources are being one of the most interesting targets for the packaging industry. In this paper, the UV-protection films were produced based on modified lignin and cellulose nanocrystals, both were extracted from the Argania nutshell. The lignin was extracted via the alkylation process followed by chemical modification using epichlorohydrin.

Value of hematological parameters for predicting patients with severe coronavirus disease 2019: a real-world cohort from Morocco.

Objective: Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2. The clinical manifestations and the evolution of patients with COVID-19 are variable. In addition to respiratory involvement, COVID-19 leads to systemic involvement and can affect the hematopoietic system.

Otomyiasis caused by Musca domestica in a child: A case report.

Introduction: Myiasis is the infestation of humans and vertebrate animals with dipterous larvae. It is a rare clinical condition, mainly observed in vulnerable people living in tropical and subtropical regions.

Case Presentation: We reported a 2-year-old boy, with history of anemia and psoriasis who was admitted to our department after discovering larvea coming out from the left ear 6 weeks ago.

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis.

Background: Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to trauma, aging, or dystrophies and impairs muscle function.

Advantages of three-dimensional printing in the management of acetabular fracture fixed by the Kocher-Langenbeck approach: randomised controlled trial.

Purpose: To compare the outcomes of the Kocher-Langenbeck reduction and fixation of the posterior structures of the acetabulum between 3D printing technique and conventional technique.

Methods: Forty-three patients who sustained fractures of the posterior part of the acetabulum were randomly assigned to two groups: 3D printing (G1; n = 20) and conventional technique (G2; n = 23). The surgical time, intra-operative blood loss, differences between pre-and post-operative haemoglobin, universal functional and radiographic scores, and complications were compared between the groups.

Immunophenotypic challenges in diagnosis of CD79a negativity in a patient with B acute lymphoblastic leukemia harboring intrachromosomal amplification of chromosome 21: a case report.

Background: Being expressed in all stages of B-cell development and having a significant value on the European Group for the Immunological Characterization of Acute Leukemias scoring system, CD79a is considered as an excellent pan-marker for lineage assignment of B cells by flow cytometry. Therefore, any lack or decrease in CD79a expression makes the diagnosis of B acute lymphoblastic leukemia cases very challenging, especially in developing country laboratories where flow cytometry analyses are not always available and, when they are, they are limited in the number of markers used for lineage assignment. Since this case is potentially interesting, we report a B acute lymphoblastic leukemia case with a lack of expression CD79a associated with intrachromosomal amplification of chromosome 21 genetic abnormality.

Visceral leishmaniasis associated with macrophage activation syndrome: Case report and literature review.

Background: The combination of visceral leishmaniasis (VL) and macrophage activation syndrome (MAS) makes the diagnosis difficult due to their similar clinical presentation, with a poor prognosis especially since the treatment is still poorly codified.We report the case of a 17-month-old female patient from Berkane, presenting for a 3 months history of anarchic fever with anemic syndrome made up of pallor and hemorrhagic syndrome made up of epistaxis. Physical examination revealed a temperature of 39 ° C, lower limbsedema, paleness of skin and mucous membranes, gingival petechiae, bleached hair, and hepatosplenomegaly.