MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3.

This study aimed to discover the effect of miR-124/STAT3 axis on the inflammation and cell apoptosis in myocardial infarction (MI) rats. Sprague-Dawley (SD) male rats were selected for establishing MI models and divided into Sham, MI, MI + anti-miR-124 and MI + Ad-miR-124 groups. Cardiac function was detected via echocardiography.

Preparation of Programmed Death-Ligand 1 Antibody Nanoparticles and Their Lung Cancer Targeting Therapeutic Effects.

The antibody nanoparticles of programmed death-ligand 1 (PD-L1) were prepared and their characterization, drug loading ability, and targeting effect were evaluated. In addition, adriamycin-loaded lipid polymer nanoparticles (hereafter referred to as nanoparticles) were synthesized by a double emulsion method and thin film dispersion method and were coupled with PD-L1 antibody nanoparticles. The cytotoxicity of nanoparticles to A549 cells was detected , and the uptake of nanoparticles was detected by flow cytometry and confocal microscopy.

Coronary artery disease associated specific modules and feature genes revealed by integrative methods of WGCNA, MetaDE and machine learning.

Purpose: Coronary artery disease (CAD) is one of the most common causes of morbidity and mortality globally. This work aimed to investigate the specific modules and feature genes associated with CAD.

Methods: Three microarray datasets were downloaded from the Gene Expression Omnibus database, which included CAD and healthy samples.

Spatial analysis of dengue fever in Guangdong Province, China, 2001-2006.

Guangdong Province is the area most seriously affected by dengue fever in China. In this study, we describe the spatial distribution of dengue fever in Guangdong Province from 2001 to 2006 with the objective of informing priority areas for public health planning and resource allocation. Annualized incidence at a county level was calculated and mapped to show crude incidence, excess hazard, and spatial smoothed incidence.