Publications by Benoit Villebonet

Publications by authors named "Benoit Villebonet"

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Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.

Jérémie Doiron Luc H Boudreau Nadia Picot Benoît Villebonet Marc E Surette

Bioorg Med Chem Lett

February 2009

Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity.

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