Publications by authors named "Benoit Blomme"
The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at each heartbeat, for an average of 40 million times per year. Myxomatous mitral valve (MMV) is the most frequent heart valve disease characterized by disruption of several valvular structures due to alterations of their ECM preventing the complete closure of the valve resulting in symptoms of prolapse and regurgitation. VIC and their ECM exhibit reciprocal dynamic processes between the mechanical signals issued from the ECM and the modulation of VIC phenotype responsible for ECM homeostasis of the valve.
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- The interaction between tumor cells and their microenvironment is vital for tumor growth, highlighting the need to study this communication for developing new cancer therapies.
- MicroRNAs (miRNAs), particularly miR-503, play a key role in this communication, as they can be transferred from endothelial cells to tumor cells through exosomes and influence tumor behavior.
- The research shows that miR-503 levels change during chemotherapy in breast cancer patients, suggesting that endothelial cells contribute to tumor modulation through miRNA secretion.