Publications by authors named "Benny Sp Fok"
Article Synopsis
- The study aimed to explore the link between specific genetic variations (SNPs) and aspirin resistance (AR) in patients using long-term aspirin therapy to understand individual responses to the medication.
- It involved 266 patients with stable coronary heart disease who took low-dose aspirin and had their blood samples analyzed to measure aspirin's effectiveness by checking thromboxane B2 levels and platelet function.
- The findings indicated that two specific SNPs were significantly associated with reduced effects of aspirin on platelet aggregation, suggesting a genetic influence on AR, though further research is needed to confirm these results.
Polymorphism Is Associated with Impaired Oral Clearance of Gliclazide in Healthy Chinese.
Pharmgenomics Pers Med
December 2019
Background: Previous studies suggest gliclazide is metabolised primarily by CYP2C19 rather than CYP2C9, unlike other sulphonylureas. and polymorphisms are more common in Asians.
Methods: We investigated the effect of CYP2C19 polymorphisms on gliclazide pharmacokinetics in 15 healthy male Chinese subjects after a single 80mg oral dose.