Publications by authors named "Benny Leshem"
All European countries are facing common challenges for delivering appropriate, evidence-based care to patients with cancer. Despite tangible improvements in diagnosis and treatment, marked differences in cancer survival exist throughout Europe. The reliable translation of new research evidence into consistent patient-oriented strategies is a key endeavour to overcome inequalities in healthcare.
View Article and Find Full Text PDFIron chelating agents, which permeate through erythrocytic and parasite membranes, are effective against Plasmodium falciparum in vitro. However, the protective effect in humans is transient. We examined the antiplasmodial capacity of several iron chelators in vitro and in vivo.
View Article and Find Full Text PDFArticle Synopsis
- T cell antigen receptor zeta chain down-regulation and decreased T cell function occur in cancer and autoimmune/infectious diseases, but the reasons for this are not fully understood.
- Sustained exposure to antigens and chronic inflammation may trigger these changes.
- Experiments on mice show that prolonged exposure to bacterial antigens can lead to zeta chain down-regulation and impaired T cell function, suggesting this response may help prevent harmful excessive immune reactions, but also potentially weaken responses against chronic diseases.