Publications by authors named "Benno C Orr"
Article Synopsis
- The study addresses the difficulty of understanding how specific sequences in the genome relate to their functions, especially with limited tools for hypermutation.
- A new platform called helicase-assisted continuous editing (HACE) is introduced, which uses CRISPR-Cas9 to induce mutations over large sections of the genome effectively.
- HACE has been applied to study mutations related to drug resistance and missplicing, and it offers a robust way to explore both coding and noncoding genetic variants to better understand their roles in biological functions.
Radiotherapy (RT) is an effective cancer treatment modality, but standard RT often causes collateral damage to nearby healthy tissues. To increase therapeutic ratio, radiosensitization via gold nanoparticles (GNPs) has been shown to be effective. One challenge is that megavoltage beams generated by clinical linear accelerators are poor initiators of the photoelectric effect.
View Article and Find Full Text PDF