Water Is K'é: Learning from the Navajo Community to Promote Early Child Health.

Background: Drinking water instead of sugary drinks is key to reducing health disparities. Since beverage habits are shaped by complex personal, community, and environmental factors, community input is critical to design any intervention promoting water.

Objectives: We worked with community partners to design a program to promote healthy beverage habits among young Navajo children.

Risk Factors for Equine Gastric Ulcer Syndrome Incidence in Adult Icelandic Riding Horses.

A high prevalence of both squamous (ESGD) and glandular (EGGD) ulcers was previously found in, mainly young, Icelandic horses coming into training for the first time. This study evaluated risk factors for gastric ulcers in Icelandic riding horses at various ages and stages of training. The horses (n = 211) were gastroscoped from 21 equine establishments across Iceland.

Knockout of the longevity gene Klotho perturbs aging- and Alzheimer's disease-linked brain microRNAs and tRNA fragments.

Overexpression of the longevity gene Klotho prolongs, while its knockout shortens lifespan and impairs cognition via altered fibroblast growth factor signaling that perturbs myelination and synapse formation; however, comprehensive analysis of Klotho's knockout consequences on mammalian brain transcriptomics is lacking. Here, we report the altered levels under Klotho knockout of 1059 long RNAs, 27 microRNAs (miRs) and 6 tRNA fragments (tRFs), reflecting effects upon aging and cognition. Perturbed transcripts included key neuronal and glial pathway regulators that are notably changed in murine models of aging and Alzheimer's Disease (AD) and in corresponding human post-mortem brain tissue.

Factors associated with safe completion of Fédération Equestre Internationale eventing cross-country (2008-2018).

Background: Equestrian eventing involves competing in three phases: dressage, jumping, and cross-country. Competitors are ranked by number of penalties accrued-with those who have fewer penalties ranked higher. Completing the cross-country phase with zero obstacle penalties is commonly referred to as 'running clear'.

Anomalous Incidence of Fatal Musculoskeletal Injury in North American 2-Year-Old Thoroughbred Racehorses in the Year 2020.

Racehorse training and racing schedules in many parts of the United States and Canada were interrupted or otherwise reduced during the first three to six months of 2020. This was an indirect consequence of mitigations to prevent the spread of the pandemic virus COVID-19. Data from the Equine Injury Database, a census-level survey of all race starts made in the USA and Canada, were used to analyse the incidence of fatalities in 2009-2022 among three age cohorts of racehorses within each year.

Towards a safer sport: Risk factors for cross-country horse falls at British Eventing competition.

Background: Equestrian eventing is a dangerous Olympic sport, with 16 rider and 69 horse fatalities at competition in the last 10 years. Despite this, there is limited research that aims to improve safety within the sport.

Objectives: The purpose of this study was to identify risk factors for horse falls, which are the leading cause of rider fatality within the sport.

Treatment of racehorse superficial digital flexor tendonitis: A comparison of stem cell treatments to controlled exercise rehabilitation in 213 cases.

Background: Overstrain of the superficial digital flexor tendon (SDFT) is a common Thoroughbred racehorse limb injury requiring treatment.

Objectives: To determine whether treatment of SDFT lesions in flat Thoroughbred racehorses with autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) or allogenic adipose-derived mesenchymal stem cells (A-MSCs) is associated with improved likelihood of returning to racing, when compared to racehorses managed with a controlled exercise rehabilitation program (CERP) alone.

Study Design: Retrospective cohort study combining clinical treatment records with race records.

Fifteen risk factors associated with sudden death in Thoroughbred racehorses in North America (2009-2021).

Objective: To identify risk factors associated with race-related sudden death in Thoroughbred racehorses in the US and Canada.

Animals: 4,198,073 race starts made by 284,387 Thoroughbred horses at 144 racetracks in the US and Canada between 2009 and 2021.

Procedures: Study data were extracted from the Equine Injury Database, which contains detailed records of 92.

Effect of moving from being extensively managed out in pasture into training on the incidence of equine gastric ulcer syndrome in Icelandic horses.

Objective: To investigate equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD) in Icelandic horses moving from pasture into training.

Animals: 81 horses (median age, 3 years; interquartile range, 1 year) from 10 farms representing 4 different Icelandic regions.

Procedures: Initial gastroscopy was undertaken within 2 weeks of moving from pasture into a training establishment.

Risk factors for lameness elimination in British endurance riding.

Background: Horse welfare is a priority in the equine sport of endurance riding. Identification and reduction of risk factors associated with elimination and lameness have been the focus of research to date, however, this has centred on international competition. National federations recognise there is a need to consider risk factors for elimination at a more local level.

Data Ethics Club: Creating a collaborative space to discuss data ethics.

Awareness and management of ethical issues in data science are becoming crucial skills for data scientists. Discussion of contemporary issues in collaborative and interdisciplinary spaces is an engaging way to allow data-science work to be influenced by those with expertise in sociological fields and so improve the ability of data scientists to think critically about the ethics of their work. However, opportunities to do so are limited.

Fédération Equestre Internationale eventing: Fence-level risk factors for falls during the cross-country phase (2008-2018).

Background: The equestrian discipline of eventing tests athletes' and horses' skill over three phases: dressage, jumping and cross-country. Falls during cross-country can be particularly serious and result in serious or fatal injury for both horse and athlete. Cross-country course and fence design are crucial contributory factors to safety.

A randomized controlled trial of the effect of supervised exercise on functional outcomes in older African American and non-Hispanic White breast cancer survivors: Are there racial differences in the effects of exercise on functional outcomes?

Background: The objective of this study was to test the hypothesis that exercise would be more effective than a support group plus Fitbit (SG+Fitbit) program in improving functional outcomes in older breast cancer survivors (BCSs) and that race would moderate the exercise effect on outcomes.

Methods: Older African American (AA) and non-Hispanic White (NHW) BCSs were purposively recruited and enrolled into the 52-week randomized controlled trial. The interventions included 20 weeks of supervised moderate-intensity aerobic and resistance training followed by 32 weeks of unsupervised exercise called IMPROVE (n = 108) and a 20-week SG+Fitbit program followed by 32 weeks of unsupervised activity (n = 105).

Factors associated with completion of Fédération Équestre Internationale endurance rides (2012-2019): Modelling success to promote welfare-oriented decisions in the equestrian sport of endurance.

Endurance riding is a popular equestrian sport organised at the international level by the Fédération Équestre Internationale (FEI). The sport involves prolonged exercise at speed over significant distances, which puts a substantial load on equine athletes' musculoskeletal systems and metabolism and contributes to the risk of injuries and other veterinary problems. The FEI employs a system of in-ride veterinary inspections aimed at early detection of such problems and elimination of horses unfit to continue in the ride.

Fédération Equestre Internationale eventing: Risk factors for horse falls and unseated riders during the cross-country phase (2008-2018).

Background: Eventing is an equestrian sport that tests athletes' and horses' skill over three phases: dressage, jumping and cross-country. Falls during the cross-country phase can have very serious outcomes up to and including death for both horse and athlete. Therefore, understanding risk factors associated with falls is essential for improving equine and human welfare.

IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics.

Background: Behavioral intervention studies in older breast cancer survivors, particularly older African American (AA) and socioeconomic status-disadvantaged breast cancer survivors, are lacking. To inform future studies, the authors examined recruitment strategies in older breast cancer survivors who participated in an exercise intervention study.

Methods: IMPROVE is a randomized trial designed to evaluate a group-based exercise intervention versus a support group (ClinicalTrials.

Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia.

Introduction: Infection of equids with Trypanosoma brucei (T. brucei) ssp. is of socioeconomic importance across sub-Saharan Africa as the disease often progresses to cause fatal meningoencephalitis.

IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Rationale, design and methods.

Background: African Americans (AA) and socioeconomic status (SES) disadvantaged older breast cancer survivors (BCS) are more likely to experience poor functional and health outcomes. However, few studies have evaluated the putative beneficial effects of exercise on these outcomes in older racial minority and SES-disadvantaged BCS.

Methods: This is a mixed-methods study that includes a randomized-controlled trial, "IMPROVE", to evaluate a group-based exercise intervention compared to a support group program in older BCS, followed by post-intervention semi-structured interviews to evaluate the intervention.

The association between clinical parameters recorded at vet gates during Fédération Equestre Internationale endurance rides and the imminent risk of elimination.

Background: Endurance competitions over distances of 80-160 km are required by Fédération Equestre Internationale (FEI) rules to be divided into a number of stages between three and six. These stages are also known as "loops". Veterinary inspections, designed to ensure horse welfare, are conducted at the end of each loop, with details recorded on a separate "vet card" for each horse.

The impact of the mandatory rest period in Fédération Equestre Internationale endurance events.

Background: Endurance riding competitions are increasingly popular, with a corresponding awareness of the frequency of Failure to Qualify (FTQ) due to lameness or metabolic problems. Fédération Equestre Internationale (FEI) rules require a minimum number of days between competitions, known as a mandatory rest period (MRP).

Objectives: To analyse the impact on FTQ outcomes of MRPs which applied between January 2014 and December 2016, and model potential changes to MRPs to establish which rule change could lead to the largest further reduction in the number of FTQ outcomes.

Fédération Equestre Internationale endurance events: Risk factors for failure to qualify outcomes at the level of the horse, ride and rider (2010-2015).

An epidemiological study of elite endurance riding was conducted using data from every Fédération Equestre Internationale (FEI) endurance event from 2010 to 2015, comprising 82,917 starts. The aim of the study was to identify risk factors associated with failure to qualify outcomes for horses during FEI endurance rides. The FEI endurance rules state that, during a ride, horses must be assessed by veterinarians several times, giving veterinarians the opportunity to prevent those horses exhibiting signs of lameness or metabolic problems from continuing further.

Fédération Equestre Internationale (FEI) endurance events: Riding speeds as a risk factor for failure to qualify outcomes (2012-2015).

This study examined the association between riding speed and elimination in Fédération Equestre Internationale (FEI) endurance events. A total of 35,061 horse starts from 1st July 2012 to 31st December 2015 were included in a multivariable logistic regression model containing 25 different risk factors. Riding speeds in individual stages ('loops') were included as individual risk factors in studying the progress of horses through loops 1-3 of each endurance ride.

Perspective of older African-American and Non-Hispanic white breast cancer survivors from diverse socioeconomic backgrounds toward physical activity: A qualitative study.

Background: We sought to explore the perspective of older breast cancer survivors (BCS) from diverse racial and socioeconomic backgrounds toward physical activity (PA) to inform the design of a PA program that fosters acceptability.

Methods: Participants included sixty women, ≥65years, within two years of treatment completion for stage I-III breast cancer. We purposely sampled ≥ten patients in each race [African-American (AA) and Non-Hispanic White (NHW)] and socioeconomic status (SES) [SES disadvantaged and SES non-disadvantaged] group.

The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis.

The lubricative, heavily glycosylated mucin-like synovial glycoprotein lubricin has previously been observed to contain glycosylation changes related to rheumatoid and osteoarthritis. Thus, a site-specific investigation of the glycosylation of lubricin was undertaken, in order to further understand the pathological mechanisms involved in these diseases. Lubricin contains an serine/threonine/proline (STP)-rich domain composed of imperfect tandem repeats (EPAPTTPK), the target for O-glycosylation.