Validation of an Ion-Pair Reverse Phase High-Performance Liquid Chromatography Method for the Detection of Major Components and Related Substances in Diquafosol Sodium Eye Drops.

A simple, feasible, isocratic elution, and stable reversed-phase high performance liquid chromatography method was established and verified. The chromatographic conditions are as follows: EF-C18H, 4.6 × 250 mm, 5 μm column; column temperature 30 °C; for the mobile phase 27.

Development and evaluation of sustained release matrix tablets of pregabalin: A case study based on quality by design to analyze the impact of variables.

The current research work describes systematic development of sustained release matrix tablets of a hydrophilic drug, pregabalin, using employing rational blend of hydrophilic polymers such as polyoxyethylene and carbomer as the release controlling polymers. As per the QbD-based approach, the patient-centric quality target product profile was defined and critical quality attributes were earmarked. Preliminary studies were conducted for screening the formulation and process variables.

mPEGylated solanesol micelles as redox-responsive nanocarriers with synergistic anticancer effect.

Unlabelled: We prepared an amphiphilic redox-responsive conjugate based on mPEGylated solanesol, solanesyl poly(ethylene glycol) dithiodipropionate (SPDP), along with its inert counterpart solanesyl poly(ethylene glycol) succinate (SPGS), which self-assembled in aqueous solution to form redox-responsive micelles. Used as efficient drug carriers for doxorubicin (DOX), the micelles acted as synergistic agents for cancer therapy. Dynamic light scattering (DLS) measurements showed that the SPDP micelles had average diameters of 111nm, which decreased to 88nm after the encapsulation of DOX.

PEGylated Solanesol for Oral Delivery of Coenzyme Q.

Coenzyme Q (CoQ) is widely used in preventive or curative treatment of cardiovascular diseases. However, CoQ exhibits an extremely low solubility in aqueous medium as well as a poor oral bioavailability. Therefore, solanesyl poly(ethylene glycol) succinate (SPGS) and CoQ were formulated as CoQ-SPGS micelles with a high content of CoQ to improve the bioavailability of CoQ in rat.

[Effects of paclitaxel loaded-drug micelles on cell proliferation and apoptosis of human lung cancer A549 cells].

This study was conducted to investigate the paclitaxel loaded by hydrazone bonds in poly(ethylene glycol)-poly(caprolactone) micelles (mPEG-PCL-PTX) on proliferation and apoptosis of human lung cancer A549 cells and its possible mechanisms of anti-tumor activity. The cell proliferation was measured with MTT assay. Flow cytometry were used to analyze the cell cycle.