Publications by authors named "Benjamin Zucol"
Subvisible particles (SVPs) are an obligatory critical quality attribute of the product, and yet, they are found in all biopharmaceutical products intended for infusion or injection. Light obscuration (LO) is the primary pharmacopeial method used to quantify SVPs. However, the method may not be equally sensitive toward all particles that can possibly occur.
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- Anthranoyl-CoA monooxygenase/reductase (ACMR) in Azoarcus evansii plays a key role in breaking down aromatic compounds by converting anthranoyl-CoA into 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA through hydroxylation and reduction processes.
- The enzyme has distinct monooxygenase and reductase domains, with the monooxygenase domain using FAD and the reductase domain utilizing FMN, highlighting a separation of functions within the enzyme.
- Structural studies suggest that the two active sites in the enzyme are independent, and the homodimeric structure of ACMR facilitates the interaction between these domains to complete the transformation of substrates