Publications by authors named "Benjamin Y Martin"
Basic Res Cardiol
May 2023
Article Synopsis
- Calcium transfer into mitochondria is key for energy production in heart cells, with differences found between male and female hearts in the handling of calcium and reactive oxygen species (ROS).
- Female heart cells show lower levels of mito-Ca and ROS but maintain respiration capacity, potentially due to better organization of electron transport chain (ETC) proteins into supercomplexes.
- The study highlights that estrogen-related factors, specifically COX7RP, play a significant role in enhancing mitochondrial supercomplex assembly in females, contributing to their cardioprotective traits compared to males, especially under stress.
