Electro-hydrodynamic extraction of DNA from mixtures of DNA and bovine serum albumin.

We report separation of genomic DNA (48 kbp) from bovine serum albumin (BSA) by the electro-hydrodynamic coupling between a pressure-driven flow and a parallel electric field. Electro-hydrodynamic extraction exploits this coupling to trap DNA molecules at the entrance of a microfluidic contraction channel, while allowing proteins and salts to be flushed from the device. Samples (10 μL) containing λ-DNA (1 ng) and BSA (0.

Rapid and Efficient Coacervate Extraction of Cationic Industrial Dyes from Wastewater.

Effluent wastewater containing dyes from textile, paint, and various other industrial wastes have long posed environmental damage. Functional nanomaterials offer new opportunities to treat these effluent wastes in an unprecedentedly rapid and efficient fashion due to their large surface area-to-volume ratio. In this work, we explore a new approach of wastewater treatment using macroionic coacervate complexes formed with zwitterionic polyampholytes and anionic inorganic polyoxometalate (POM) nanoclusters to extract methylene blue (MB) dye as well as other cationic industrial dyes from model wastewater.

Non-cognitive factors predicting success in orthopedic surgery residency.

Admissions to orthopedic surgery is a highly competitive process. Traditionally measures such as United States Medical Licensing Examination (USMLE) Step 1, class rank, AOA status have been major determinants in the ranking process. However, these traditional objective measures show mixed correlation to clinical success in orthopedic surgery residency.

Selective ion exchange governed by the Irving-Williams series in K2Zn3[Fe(CN)6]2 nanoparticles: toward a designer prodrug for Wilson's disease.

The principle of the Irving-Williams series is applied to the design of a novel prodrug based on K2Zn3[Fe(CN)6]2 nanoparticles (ZnPB NPs) for Wilson's disease (WD), a rare but fatal genetic disorder characterized by the accumulation of excess copper in the liver and other vital organs. The predetermined ion-exchange reaction rather than chelation between ZnPB NPs and copper ions leads to high selectivity of such NPs for copper in the presence of the other endogenous metal ions. Furthermore, ZnPB NPs are highly water-dispersible and noncytotoxic and can be readily internalized by cells to target intracellular copper ions for selective copper detoxification, suggesting their potential application as a new-generation treatment for WD.

Gallium analogue of soluble Prussian blue KGa[Fe(CN)6]·nH2O: synthesis, characterization, and potential biomedical applications.

The gallium analogue of the soluble Prussian blue with the formula KGa[Fe(CN)6]·nH2O is synthesized and structurally characterized. A simple aqueous synthetic procedure for preparing nanoparticles of this novel coordination polymer is reported. The stability, in vitro ion exchange with ferrous ions, cytotoxicity, and cellular uptake of such nanoparticles coated with poly(vinylpyrrolidone) are investigated for potential applications of delivering Ga(3+) ions into cells or removing iron from cells.