Publications by authors named "Benjamin Ungar"
Background: Cicatricial alopecias are chronic, progressive scarring hair-loss conditions. Molecular dysregulation is not fully understood, hindering treatment development. Th1/IFNγ signaling and Janus kinase dysregulation has shown involvement, providing rationale for this phase 2a trial with Tyrosine kinase 2/Janus kinase 1 inhibitor brepocitinib.
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- * Researchers studied 8,319 people with rosacea and compared them to 33,276 others without it to see if there was a connection.
- * They found that people with rosacea were more likely to have certain gut diseases, but there was no strong link to a condition called microscopic colitis.
Background: Alopecia areata (AA) is a chronic, nonscarring hair-loss disorder associated with significant quality-of-life impairment and limited treatment options. AA has been recently linked to atopy and shown to exhibit both Th1- and Th2-driven inflammation. However, a comprehensive molecular and cellular characterization across blood and scalp compartments in both atopic and nonatopic patients is lacking.
View Article and Find Full Text PDFAlopecia areata (AA) is nonscarring hair loss characterized by Th1 and concomitant Th2 skewing, particularly in atopic patients. Despite novel developments for adult AA, safe and effective treatments for pediatric patients remain limited. Dupilumab, with a well-studied safety profile, may have therapeutic potential for atopic pediatric AA.
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- * Monitoring these disorders during treatment is crucial to assess therapy effectiveness and identify side effects, though traditional symptom-based assessments have limitations.
- * The review discusses the skin barrier's anatomy and introduces atomic-force microscopy as an advanced method to quantitatively track SBF disorders and treatment responses, advocating for its greater use in clinical practice.
Beyond Avoidance: Advanced Therapies for Contact Dermatitis.
J Allergy Clin Immunol Pract
September 2024
Contact dermatitis (CD) is a common and burdensome condition divided into irritant contact dermatitis and allergic contact dermatitis. Treatment relies on accurate diagnosis and identification of the trigger, because definitive treatment is irritant or allergen avoidance. However, avoidance is not always possible, such as when the patient is reacting to a necessary medical device, when the trigger is integral to the patient's occupation, and when avoidance is practically untenable.
View Article and Find Full Text PDFPurpose: Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the database, examines the association between the two conditions.
Materials And Methods: A nested case-control comparison was used to examine the association, identifying cases with SNOMED codes 418363000 (pruritus) and 68154008 (CC). Matching was performed on a 1:4 ratio by age, sex, and ethnicity using the MatchIt package in R, followed by maximum likelihood method to estimate odds ratios (ORs) and 95% confidence intervals from 2x2 contingency tables.
Melanoma case reports show variations in treatment by age and sex.
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