Nonmucinous adenocarcinoma of the cecum presenting as appendicitis complicated by hepatic abscess.

A 59-year-old man presenting with right upper quadrant pain was found to have hepatic abscesses on CT imaging. After draining the abscess, a repeat CT 3 weeks later indicated that the cause of the hepatic abscesses was appendicitis. Upon surgical resection of the base of the cecum and appendix, an adenocarcinoma was demonstrated along the cecal wall both invading and occluding the appendix.

Development of multiorgan pathology in the wpk rat model of polycystic kidney disease.

Rodent models of polycystic kidney disease (PKD) have provided valuable insight into the cellular changes associated with cystogenesis in humans. The present study characterizes the morphology of renal and extrarenal pathology of autosomal recessive PKD induced by the wpk gene in Wistar rats. In wpk(-/-) rats, proximal tubule and collecting duct cysts develop in utero and eventually consume the kidney.