Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.

Background: Bariatric surgery has been shown to result in weight loss, improved hemoglobin A1C, and decreased mortality but can also lead to bone loss and increased fracture rates. Serum IGFBP-2 is elevated in patients after bariatric surgery and although it may lead to improved blood glucose, may also drive bone resorption, and inhibit IGF-I action. This study tested the hypothesis that Igfbp2-/- mice were acutely protected from bone loss after vertical sleeve gastrectomy (VSG).

Pediatric Anterior Cruciate Ligament Reconstruction: A Reason Not to Wait Until Skeletal Maturity.

Anterior cruciate ligament (ACL) tears within the skeletally immature population give rise to controversy regarding the timing of treatment decisions due to the concern of iatrogenic damage to the open physis. Physis disruption from the required intraoperative graft tunnel drilling can lead to growth disturbance, thus ligament reconstruction is not without risk. Nonoperative management carries the risk of future damage to the menisci and cartilage as an ACL-deficient knee can be unstable.

Traumatic Simultaneous Bilateral Knee Dislocation: A Case Report.

Bilateral knee dislocation is an extremely rare and devastating injury to the knee joint. This injury is a true emergency as concomitant injuries may threaten life and limb. Here, we report the case of a 26-year-old male patient who sustained bilateral knee dislocation due to a high-velocity motor vehicle accident.

Management of bilateral osteochondritis dissecans of the trochlea in a skeletally immature patient.

Osteochondritis dissecans (OCD) lesions are injuries that occur more commonly in the skeletally immature population. In most cases, the aetiology is not well understood, but fortunately, many OCD lesions may heal on their own over time, particularly in skeletally immature patients with open physes. Conversely, if the lesion is considered unstable, surgical intervention may be required.

Prolonged standing increases lower limb arterial stiffness.

Purpose: Standing workstations have recently been promoted as a healthy alternative to sitting. However, it is unknown how prolonged standing affects arterial stiffness, a prognostic indicator of cardiovascular health. The purpose of this study was twofold: to observe changes in arterial stiffness, as assessed by pulse wave velocity (PWV), with a 2-h bout of standing, and to determine if short, intermittent walking bouts provide a comparative advantage to standing alone.