Genotypic Characterisation and Antimicrobial Resistance of Extended-Spectrum β-Lactamase-Producing in Humans, Animals, and the Environment from Lusaka, Zambia: Public Health Implications and One Health Surveillance.

Background: Extended-spectrum β-lactamases (ESBL) in are a serious concern due to their role in developing multidrug resistance (MDR) and difficult-to-treat infections.

Objective: This study aimed to identify ESBL-carrying strains from both clinical and environmental sources in Lusaka District, Zambia.

Methods: This cross-sectional study included 58 ESBL-producing strains from hospital inpatients, outpatients, and non-hospital environments.

Antimicrobial Resistance Patterns and Risk Factors Associated with ESBL-Producing and MDR in Hospital and Environmental Settings in Lusaka, Zambia: Implications for One Health, Antimicrobial Stewardship and Surveillance Systems.

Antimicrobial resistance (AMR) is a public health problem threatening human, animal, and environmental safety. This study assessed the AMR profiles and risk factors associated with Escherichia coli in hospital and environmental settings in Lusaka, Zambia. This cross-sectional study was conducted from April 2022 to August 2022 using 980 samples collected from clinical and environmental settings.

Antimicrobial resistance patterns of bacterial pathogens their distribution in university teaching hospitals in Zambia.

To determine the antimicrobial resistance patterns of bacterial pathogens from urine, blood and wound infections and their distribution by age, sex and location. A total of 49,168 samples were collected, processed and analyzed. Multidrug resistance was observed in almost all bacterial pathogens in blood urine and wound swabs.

Antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia at a tertiary hospital in Zambia.

Bloodstream infections and antimicrobial resistance cause global increases in morbidity and mortality. We evaluated the antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia in humans. We conducted a retrospective cross-sectional study at the University Teaching Hospitals in Lusaka, Zambia, using Laboratory Information Systems.