Publications by authors named "Benjamin S Lee"
Background: Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer's disease with cerebrovascular disease (AD + CVD).
Results: We detected modulation of several redox proteins in the temporal lobe of AD + CVD subjects, and we observed sex-specific alterations in the white matter (WM) and mitochondria proteomes of female patients.
Article Synopsis
- Infants on prolonged parenteral nutrition are at risk of PN-associated cholestasis (PNAC), which can lead to serious liver issues; fish oil-based lipid preparation (FOLP) may help.
- A double-blind trial assessed FOLP's effects compared to soy-based lipid preparation (SLP) on PNAC progression, liver function, and growth in infants dependent on PN for over two weeks.
- While there was no significant difference in PNAC reversal between groups, FOLP showed less increase in harmful liver enzymes and recovery linked to increased enteral nutrition, suggesting a potential benefit over SLP.
The obese Zucker rat (OZR) spontaneously develops hyperlipidemia, insulin resistance, and microalbuminuria. In this study, the initial metabolic, functional, and glomerular pathology in young OZR fed with an atherogenic diet resembles the characteristics of metabolic syndrome. Hyperlipidemia and other metabolic derangement cause early glomerular damage in OZR by 10 weeks of age, before overt diabetes is developed.
View Article and Find Full Text PDFObjective: We sought to determine 1) long-term lipid-lowering treatment patterns; 2) cholesterol goal attainment rates and possible determinants of goal achievement; and 3) effects of cholesterol goal attainment on coronary events in hospitalized Hong Kong patients.
Methods: In this retrospective cohort analysis, records of two public Hong Kong hospitals were reviewed for 196 adults (69% with coronary heart disease (CHD) or CHD-risk equivalent) who received at least one lipid-lowering therapy during hospitalization. Low-density lipoprotein cholesterol (LDL-C) targets were <2.
Objective: To assess the effectiveness of a "stress dose" of hydrocortisone for rescue treatment of refractory hypotension and adrenocortical insufficiency of prematurity in very low birth weight (VLBW) infants. We hypothesized that significantly more VLBW infants who were receiving dopamine > or =10 microg/kg per min could wean off vasopressor support 72 hours after treatment with hydrocortisone.
Methods: A double-blind, randomized, controlled study was conducted in a university neonatal center.