Publications by authors named "Benjamin Rodrigues"
Therapeutic hypothermia is an effective therapy for moderate-to-severe hypoxic-ischemic encephalopathy (HIE) in infants born at term or near-term in high-resource settings. Yet there remains a substantial proportion of infants who do not benefit or who will have significant disability despite therapeutic hypothermia. Novel investigational therapies that may confer additional neuroprotection by targeting known pathogenic mechanisms of hypoxic-ischemic brain injury are under development.
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- B-cell chronic lymphocytic leukemia (CLL) is the most common leukemia in humans and is linked to the TCL1 oncogene, which promotes a similar aggressive form of leukemia in mice.
- Research identified that the Tcl1 protein interacts with the DNA methyltransferases Dnmt3A and Dnmt3B, affecting their function.
- Tcl1 overexpression was found to inhibit Dnmt3A activity and reduce DNA methylation levels, suggesting that decreased DNA methylation is a potential mechanism in the development of leukemia.