Publications by authors named "Benjamin R Rood"
Article Synopsis
- * The article outlines a typical SIRM workflow, emphasizing the importance of experimental controls, like pharmacological inhibitors, to enhance data reliability and understanding of metabolic processes.
- * The integration of radiolabeled tracers and extracellular flux analyses with SIRM is showcased as a way to improve overall interpretation of data, leading to better biological insights.
Previous studies indicate that mitochondria-localized lactate dehydrogenase (mLDH) might be a significant contributor to metabolism. In the heart, the presence of mLDH could provide cardiac mitochondria with a higher capacity to generate reducing equivalents directly available for respiration, especially during exercise when circulating lactate levels are high. The purpose of this study was to test the hypothesis that mLDH contributes to striated muscle bioenergetic function.
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