Publications by authors named "Benjamin Popp"
Article Synopsis
- Pathologists traditionally struggle with consistency while interpreting kidney allograft biopsies using the Banff system due to reliance on memory and manual processes for scoring.
- A new web-based "smart template" has been developed that utilizes additional diagnostic information and automated decision-making to enhance the accuracy of component scoring and diagnosis.
- This innovative software-assisted approach significantly reduces human errors, improves correlation with kidney function, and prepares for future integration with artificial intelligence in biopsy evaluation.
Our understanding of tissue-resident memory T (T) cell biology has been largely developed from acute infection models in which antigen is cleared and sterilizing immunity is achieved. Less is known about T cells in the context of chronic antigen persistence and inflammation. We investigated factors that underlie T maintenance in a kidney transplantation model in which T cells drive rejection.
View Article and Find Full Text PDFWe report a case of a 42-year-old woman (Gravida 1, Para 1) who presented in her third trimester of pregnancy with a photo distributed eruption and arthralgias and was subsequently diagnosed with dermatomyositis. She had an emergency Caesarean section at 34 weeks plus 6 days gestation due to decreased fetal movements and non-reassuring fetal heart rate. Her placenta was sent for histopathology and showed features of massive perivillous fibrin deposition.
View Article and Find Full Text PDFExcellent short-term survival after pediatric liver transplantation (LT) has shifted attention toward the optimization of long-term outcomes. Despite considerable progress in imaging and other noninvasive modalities, liver biopsies continue to be required to monitor allograft health and to titrate immunosuppression. However, a standardized approach to the detailed assessment of long-term graft histology is currently lacking.
View Article and Find Full Text PDFBackground: Histopathologic features of late graft dysfunction (LGD) in endomyocardial biopsies (EMBs) after pediatric heart transplantation (HT) have been incompletely described and rarely quantified. We employed automated, morphometric analysis of whole-slide EMB images to objectively quantify fibrosis and microvasculopathy after pediatric HT.
Methods: Nine recipients with clinical LGD were matched with controls on age, listing diagnosis, crossmatch and time since HT.
Article Synopsis
- The study found a high incidence of inflammatory bowel disease (IBD) in Australia, highlighting the need for a registry to analyze disease severity and complications over four years.
- A total of 252 patients were monitored, with the majority suffering from Crohn's disease (CD) showing significant hospitalization and treatment needs early in their disease course.
- The research identified risk factors for hospitalization and surgery, noting that certain disease characteristics, like ileal involvement and high C-reactive protein levels, are linked to more severe outcomes in both Crohn's disease and ulcerative colitis (UC).