Publications by authors named "Benjamin N Locher"
Article Synopsis
- - Clonal hematopoiesis (CH) is the increase of specific blood stem cell clones due to genetic mutations, linked to serious health issues like cancers and cardiovascular diseases, which raise mortality risk.
- - Lymphoid clonal hematopoiesis (L-CH) affects a wider range of genes but is less common and harder to detect compared to its myeloid counterparts.
- - The study presents a targeted sequencing method for accurately identifying CH in bone marrow or blood samples, emphasizing DNA isolation, library preparation, and computational analysis for reliable variant detection.
Purpose: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking.
Patients And Methods: To elucidate the full spectrum of genomic alterations, samples from 340 patients with previously untreated PMBCL were investigated by whole-genome (n = 20), whole-exome (n = 78), and targeted (n = 308) sequencing.
Objective: We investigated the possibility of linking the data of the Swiss Laboratory for Particle Analysis (Silag), a valuable but incomplete data source in the field of asbestos-related diseases, to the Swiss National Cohort (SNC). With the resulting comprehensive dataset, we intended to provide a source for further research in the field. We also conducted preliminary analyses of data focusing on occupations and regional distribution of malignant pleural mesothelioma cases.
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