Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype.

Introduction: The sticky platelet syndrome (SPS) seems to be a common cause of thrombosis, although no molecular substrate to explain platelet hyperaggregability has been found.

Objective: To analyze an association between the SPS phenotype and the platelet glycoprotein (GP) IIIa PL(A1/A2) (human platelet antigen [HPA]-1a/b) gene polymorphism.

Methods: Along an 18-month period, Mexican mestizo thrombophilic patients were prospectively accrued.

[Skin tags and Acanthosis nigricans: association with insulin resistance and overweight in Mexican children].

Background: Childhood overweight and obesity are a notorious health problem around the world that may lead to an increase in insulin resistance and metabolic syndrome. Acanthosis nigricans (AC) and skin tags (ST) are skin markers that can help to obtain an early diagnose of these metabolic disorders.

Objective: To determine whether such skinmarkers (ST and AN), correlate with insulin resistance based on the assessment of the homeostasis model of insulin resistance (HOMA-IR), and also with overweight and obesity.