Frameless, Virtual Cone Linac-based Stereotactic Radiosurgery for Essential & Parkinsonian Tremor: A Phase I/II Prospective Clinical Trial (S35.001).

Objective: To evaluate the safety and efficacy of a modern linear accelerator with non-invasive thermoplastic mask-based immobilization as an alternative treatment for medically refractory tremor.

Background: Essential and Parkinsonian tremors are prevalent movement disorders impacting millions globally. Although Gamma Knife radiosurgery remains a conventional treatment for these tremors, it demands invasive frame immobilization, long-treatment time, & periodic Co-60 source replacements.

Connectomic-guided stereotactic radiosurgery thalamotomy for tremor: a patient-specific approach to enhance outcomes.

Objective: Stereotactic radiosurgery (SRS) is an effective treatment for refractory tremor. However, the lack of reliable patient-specific targeting biomarkers leads to varying outcomes. Although connectomic-based targeting is commonly used in deep brain stimulation, its application in SRS is limited.

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway.

Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification and expression of AR splice variants, demonstrating that AR remains a key therapeutic target in advanced disease. For the first time we show that IKBKE drives AR signalling in advanced PC.