Publications by authors named "Benjamin Marchandot"
Aims: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infarction, pathologies often associated with low-grade inflammation. This cross-sectional study aims to investigate whether low-grade inflammation regulates SGLT2 expression and function in human vasculature, heart, and endothelial cells (ECs).
Methods And Results: Human internal thoracic artery (ITA), left ventricle (LV) specimens, and cultured porcine coronary artery ECs were used.
Background: Despite scarce data, invasive mechanical ventilation (MV) is widely suggested as first-line ventilatory support in cardiogenic shock (CS) patients. We assessed the real-life use of different ventilation strategies in CS and their influence on short and mid-term prognosis.
Methods: FRENSHOCK was a prospective registry including 772 CS patients from 49 centers in France.
Article Synopsis
- - Pathological tissues produce various substances, including extracellular vesicles (EVs) from active or dying cells.
- - EVs found in diseased heart valves may play a significant role in the development of valve thrombosis.
- - In cases of human aortic stenosis, EVs can activate valvular endothelial cells, causing dysfunction and increasing the chances of blood clotting.
Background: Cardiogenic shock and sepsis are severe haemodynamic states that are frequently present concomitantly, leading to substantial mortality. Despite its frequency and clinical significance, there is a striking lack of literature on the outcomes of combined sepsis and cardiogenic shock.
Methods: FRENSHOCK was a prospective registry including 772 patients with cardiogenic shock from 49 centres.
Article Synopsis
- * In a study involving 772 patients with cardiogenic shock, 21.3% had CKD, and these patients were generally older and had more health issues, which contributed to increased mortality.
- * Renal replacement therapy (RRT) was associated with a higher risk of death regardless of CKD status, highlighting the need for collaborative care between cardiac and kidney specialists to better manage these patients.
Article Synopsis
- There is new research showing that endometriosis, a health problem affecting many women, might be connected to heart disease.
- Endometriosis causes issues with reproductive organs and involves long-term inflammation.
- The study wants doctors to pay more attention to how endometriosis can also affect heart health.
Background: The effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied. Thus, this study investigated the association between guideline-directed heart failure (HF) medical therapy (GDMT) and one-year survival rate in patients who are post-CS.
Methods And Results: FRENSHOCK (French Observatory on the Management of Cardiogenic Shock in 2016) registry was a prospective multicenter observational survey, conducted in metropolitan French intensive care units and intensive cardiac care units.
Article Synopsis
- The study examines heart failure and cardiogenic shock (CS) in older adults, highlighting that the incidence is rising due to an aging population, with limited data available on this demographic.
- The research involved a registry called FRENSHOCK, which included 772 CS patients, revealing that 30.6% were over 75 years old, with higher comorbidities and lower treatment intensity compared to younger patients.
- Results indicated that older adults have more than double the risk of death at 1 month and 1 year post-CS, emphasizing the need for targeted research to determine effective treatment strategies for this age group.
Background: COVID-19 is associated with an increased risk of cardiovascular complications. Although cytokines have a predominant role in endothelium damage, the precise molecular mechanisms are far from being elucidated.
Objectives: The present study hypothesized that inflammation in patients with COVID-19 contributes to endothelial dysfunction through redox-sensitive SGLT2 overexpression and investigated the protective effect of SGLT2 inhibition by empagliflozin.
Background: Cardiovascular disease and cancer are the two leading causes of mortality worldwide, and their association presents a therapeutic challenge. Current data regarding the prognosis of active cancer in patients undergoing transcatheter aortic valve replacement are conflicting.
Aim: To determine the impact and prognosis of active cancer in transcatheter aortic valve replacement.
Background: Cardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes between SVT-triggered and non-SVT-triggered CS.
View Article and Find Full Text PDFBackground: Gender-related differences have been reported in atrial fibrotic remodeling and prognosis of atrial fibrillation (AF) patients after ablation. We assessed in persistent AF the regional distribution of left atrial (LA) bipolar voltage and the extent of low-voltage zones (LVZ) according to gender as well as the results of a voltage-guided substrate ablation.
Methods: Consecutive patients who underwent a voltage-guided AF ablation were enrolled.
Idiopathic dilated cardiomyopathy (IDCM) is one of the most common forms of nonischemic cardiomyopathy worldwide, possibly leading to cardiogenic shock (CS). Despite this heavy burden, the outcomes of CS in IDCM are poorly reported. Based on a large registry of unselected CS, our aim was to shed light on the 1-year outcomes after CS in patients with and without IDCM.
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- The study investigates the impact of skin mottling on patients with cardiogenic shock, finding that nearly 39% of patients showed mottling at admission, which is linked to worse outcomes.
- In a cohort of 772 patients, those with mottling had higher rates of invasive support, longer hospital stays, and increased mortality at both 30 days and 1 year compared to those without mottling.
- The study concludes that skin mottling can be a valuable assessment tool in guiding therapy for cardiogenic shock patients, indicating the need for more aggressive treatment to improve survival chances.
Background: Bioprosthetic valve thrombosis is a complication of transcatheter aortic valve replacement (TAVR). It is believed to be platelet independent, mainly driven by contact phase activation, and more likely to be targeted by oral anticoagulant (OAC).
Case Summary: We report case of an 86-year-old man with history of TAVR, who presented an early TAVR aortic valve thrombosis occurring in the context of heparin-induced thrombocytopenia (HIT) and pulmonary embolism.
Transcatheter aortic valve implantation (TAVI) has become an alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis in elderly and comorbid population. Significant improvement in heart function has been observed in patients undergoing TAVI, but numerous patients are readmitted to hospital for heart failure (HF). Moreover, repeat HF hospitalization is strongly associated with an adverse prognosis and increases the financial burden of health care.
View Article and Find Full Text PDFCharacteristics, management, and outcomes of active cancer patients with cardiogenic shock.
Eur Heart J Acute Cardiovasc Care
October 2023
Article Synopsis
- This study explored the characteristics, management, and outcomes of patients with active cancer who were admitted for cardiogenic shock, finding that they made up about 6.6% of the 772 enrolled patients.
- Although active cancer patients had similar initial in-hospital outcomes as non-cancer patients, they required more intensive drug management but received less mechanical support.
- While both groups had similar 30-day mortality rates, the active cancer group had significantly higher long-term mortality rates at 1 year, indicating that active cancer dramatically impacts survival after initial treatment for cardiogenic shock.
Article Synopsis
- * The study found that a prolonged closure time of adenosine diphosphate (CT-ADP) after the procedure, defined as greater than 180 seconds, further increased this risk, particularly in patients with AF.
- * Multivariate analysis indicated that AF patients with CT-ADP >180 seconds were 3.9 times more likely to experience MLBCs, highlighting the importance of monitoring hemostatic disorders in this population.
Background: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to evaluate 1-year outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS.
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