Spectrotemporal cues and attention jointly modulate fMRI network topology for sentence and melody perception.

Speech and music are two fundamental modes of human communication. Lateralisation of key processes underlying their perception has been related both to the distinct sensitivity to low-level spectrotemporal acoustic features and to top-down attention. However, the interplay between bottom-up and top-down processes needs to be clarified.

Long-Horizon Associative Learning Explains Human Sensitivity to Statistical and Network Structures in Auditory Sequences.

Networks are a useful mathematical tool for capturing the complexity of the world. In a previous behavioral study, we showed that human adults were sensitive to the high-level network structure underlying auditory sequences, even when presented with incomplete information. Their performance was best explained by a mathematical model compatible with associative learning principles, based on the integration of the transition probabilities between adjacent and nonadjacent elements with a memory decay.

Phosphoproteome analysis of the crosstalk between sumoylation and phosphorylation in mouse spermatocytes.

Spermatogenesis is supported by various posttranslational modifications. There is growing evidence supporting a crosstalk between sumoylation and phosphorylation in different cell types. We have recently shown that inhibition of global sumoylation with a sumoylation inhibitor (Ginkgolic acid, GA) arrested purified mouse spermatocytes in vitro; the spermatocytes could not condense chromatin and disassemble the synaptonemal complex.

Retrospective evaluation of hypersensitivity reactions and anaphylaxis in dogs (2003-2014): 86 cases.

Objective: To characterize anaphylactic reactions in dogs, including clinical signs, severity, treatments, prognosis, and estimated incidence. To determine whether glucocorticoids influence clinical recovery and survival.

Design: Retrospective study between January 1, 2003 and April 28, 2014.

Humans parsimoniously represent auditory sequences by pruning and completing the underlying network structure.

Successive auditory inputs are rarely independent, their relationships ranging from local transitions between elements to hierarchical and nested representations. In many situations, humans retrieve these dependencies even from limited datasets. However, this learning at multiple scale levels is poorly understood.

[Conservative management of distal radius fractures].

Distal radius fractures are the third most frequent fractures in Germany. The decision for conservative treatment and the weighing up of surgical treatment need an exact consideration of the indications based on instability criteria and the extent of possible articular involvement. Indications for an emergency operation must be excluded.

Lessons learned during the sliding gantry CT implementation in a trauma suite.

Purpose: Early detection of bleeding is important for managing trauma cases in the emergency department (ED). Several trauma suites are equipped with computed tomography (CT) scanners to reduce the time to CT. In the last decade, sliding gantry CT has been implemented in trauma suites, highlighting conventional techniques' advantages.

Tracking transitional probabilities and segmenting auditory sequences are dissociable processes in adults and neonates.

Since speech is a continuous stream with no systematic boundaries between words, how do pre-verbal infants manage to discover words? A proposed solution is that they might use the transitional probability between adjacent syllables, which drops at word boundaries. Here, we tested the limits of this mechanism by increasing the size of the word-unit to four syllables, and its automaticity by testing asleep neonates. Using markers of statistical learning in neonates' EEG, compared to adult behavioral performances in the same task, we confirmed that statistical learning is automatic enough to be efficient even in sleeping neonates.

The unequal impact of Covid-19 on the lives and rights of the children of modern slavery survivors, children in exploitation and children at risk of entering exploitation.

This article discusses the unequal impact of Covid-19 on the lives of the children of survivors of modern slavery, child victims of exploitation and children at risk of exploitation in the UK. It draws on research that has analysed the risks and impacts of Covid-19 on victims and survivors of modern slavery. It explores how pandemic responses may have hindered these children's rights to education, food, safety, development and participation and representation in legal processes.

Sleeping neonates track transitional probabilities in speech but only retain the first syllable of words.

Extracting statistical regularities from the environment is a primary learning mechanism that might support language acquisition. While it has been shown that infants are sensitive to transition probabilities between syllables in speech, it is still not known what information they encode. Here we used electrophysiology to study how full-term neonates process an artificial language constructed by randomly concatenating four pseudo-words and what information they retain after a few minutes of exposure.

Automated Pipeline for Infants Continuous EEG (APICE): A flexible pipeline for developmental cognitive studies.

Infant electroencephalography (EEG) presents several challenges compared with adult data: recordings are typically short and heavily contaminated by motion artifacts, and the signal changes throughout development. Traditional data preprocessing pipelines, developed mainly for event-related potential analyses, require manual steps. However, larger datasets make this strategy infeasible.

A spatiotemporal machine learning approach to forecasting COVID-19 incidence at the county level in the USA.

With COVID-19 affecting every country globally and changing everyday life, the ability to forecast the spread of the disease is more important than any previous epidemic. The conventional methods of disease-spread modeling, compartmental models, are based on the assumption of spatiotemporal homogeneity of the spread of the virus, which may cause forecasting to underperform, especially at high spatial resolutions. In this paper, we approach the forecasting task with an alternative technique-spatiotemporal machine learning.

Prehospital FAST reduces time to admission and operative treatment: a prospective, randomized, multicenter trial.

Background: The focused assessment with sonography in trauma (FAST) exam is an established trauma care diagnostic procedure. Ultrasound performed during prehospital care can improve early treatment and management of the patients. In this prospective randomized clinical trial, we wanted to assess whether a pre-hospital FAST (p-FAST) influences pre-hospital strategy and the time to operative treatment.

Effects of Gynostemma pentaphyllum on spinal cord motor neurons and microglial cells in vitro.

The regenerative capability of spinal cord neurons is limited to impossible. Thus, experimental approaches supporting reconstruction/regeneration are in process. This study focused on the evaluation of the protective potency of an extract from Gynostemma pentaphyllum (GP), a plant used in traditional medicine with anti-oxidative and neuroprotective activities, in vitro on organotypic spinal cord cultures, the motor-neuron-like NSC-34 cell line and the microglial cell line BV-2.

Remarks on the analysis of steady-state responses: Spurious artifacts introduced by overlapping epochs.

Periodic and stable sensory input can result in rhythmic and stable neural responses, a phenomenon commonly referred to as neural entrainment. Although the use of neural entrainment to investigate the regularities the brain tracks has increased in recent years, the methods used for its quantification are not well-defined in the literature. Here we argue that some strategies used in previous papers, are inadequate for the study of steady-state response, and lead to methodological artefacts.

Effect of 4DryField® PH on blood loss in hip bipolar hemiarthroplasty following intracapsular femoral neck fracture - a randomized clinical trial.

Background: One of the most common complications of hip arthroplasty is excessive blood loss that could necessitate allogenic blood transfusion, which is further associated with other complications, such as infections, transfusion reactions or immunomodulation. In gynecology, 4DryField®PH, an absorbable polysaccharide-based formulation, is used for hemostasis and adhesion prophylaxis. In this study, we evaluated its hemostatic effect in patients undergoing hip bipolar hemiarthroplasty following intracapsular femoral neck fracture.

The impact of a qualified medical documentation assistant on trauma room management.

Purpose: To improve quality of trauma room management, intra- and inter-hospital benchmarking are important tools. However, primary data quality is crucial for benchmarking reliability. In this study, we analyzed the effect of a medical documentation assistant on documentation completeness in trauma room management in comparison to documentation by physicians involved in direct patient treatment.

Differentiation of NSC-34 cells is characterized by expression of NGF receptor p75, glutaminase and NCAM L1, activation of mitochondria, and sensitivity to fatty acid intervention.

Motor neuronal damage due to diseases, traumatic insults or de-afferentation of the spinal cord is often incurable because of poor intrinsic regenerative capacity. Hence, medical basic research has to provide a better understanding of development-/regeneration-related cellular processes as only way to develop new and successful therapeutic strategies. Here, we investigated the neuronal differentiation of the NSC-34 hybrid cell line, which is an accepted model for spinal cord motor neurons.

Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas.

Spermatogenesis is regulated by a complex network of posttranslation modifications. Sumoylation (a modification by small ubiquitin-like modifiers, or SUMO proteins) was identified as an important cellular event in different cell types. SUMO proteins are highly expressed in the testis, and their role during spermatogenesis has begun to be elucidated.

Normoxic post-ROSC ventilation delays hippocampal CA1 neurodegeneration in a rat cardiac arrest model, but does not prevent it.

The European Resuscitation Guidelines recommend that survivors of cardiac arrest (CA) be resuscitated with 100% O and undergo subsequent-post-return of spontaneous circulation (ROSC)-reduction of O supply to prevent hyperoxia. Hyperoxia produces a "second neurotoxic hit," which, together with the initial ischemic insult, causes ischemia-reperfusion injury. However, heterogeneous results from animal studies suggest that normoxia can also be detrimental.

Distinct sensitivity to spectrotemporal modulation supports brain asymmetry for speech and melody.

Does brain asymmetry for speech and music emerge from acoustical cues or from domain-specific neural networks? We selectively filtered temporal or spectral modulations in sung speech stimuli for which verbal and melodic content was crossed and balanced. Perception of speech decreased only with degradation of temporal information, whereas perception of melodies decreased only with spectral degradation. Functional magnetic resonance imaging data showed that the neural decoding of speech and melodies depends on activity patterns in left and right auditory regions, respectively.

Existence and role of standard operating procedures in the emergency department : A national online survey.

Background: In recent years, increases in the number of patients in emergency departments (ED) have led to continuous work intensification. To handle this problem, the treatment effectiveness has to be maximized. One strategy that may help to optimize workflow is the use of standard operating procedures (SOPs).

Implementation of Emergency Department Performance Benchmarking Using R and LaTeX.

The German Emergency Department Data Registry (GEDD-registry, AKTIN) provides an infrastructure for collecting and querying up-to-date medical records in a distributed manner. Within this framework, a benchmark report on cross-institutional comparison using the program R is prepared using routine data of participating hospitals. Currently, 16 emergency departments (EDs) routinely transfer data of 1,200 to approximately 5,000 patients per month to a federated GEDD-registry datawarehouse.