Publications by authors named "Benjamin Lehrman"
Introduction: Historically, a zone II hematoma mandated exploration after penetrating trauma, but this has been challenged given potentially higher nephrectomy rates and the advent of therapeutic endovascular and endoscopic interventions. We hypothesized penetrating mechanism was not a predictor for delayed intervention in the modern era.
Methods: This single-center, retrospective study included renal trauma patients from 3/2019 to 6/2022.
Article Synopsis
- Trauma surgical guidance suggests using intraoperative angiography (IA) when a pulse is not detected after vascular repair of injured limbs.
- A study analyzed data from the Prospective Observational Vascular Injury Trial involving patients aged over 15 who had vascular injuries needing surgery between 2013 to 2021.
- Results indicated that while IA improved the rate of immediate surgical revisions (22% vs 9% when no pulse was detected), it did not lead to higher reoperation rates during hospitalization, emphasizing the importance of IA training for surgeons handling vascular trauma.
Background: Although many genes have been implicated as hypertension candidates, to date, few studies have integrated different types of genomic data for the purpose of biomarker selection.
Methods: Applying a newly proposed sparse representation based variable selection (SRVS) method to the Genetic Analysis Workshop19 data, we analyzed a combined data set consisting of 11522 gene expressions and 354893 single-nucleotide polymorphisms (SNPs) from 397 subjects (case/control: 151/246), with the aim to identify potential biomarkers for blood pressure using both gene expression measures and SNP data.
Results: Among the top 1000 variables (SNPs/gene expressions = 575/425) selected, the bioinformatics analysis showed that 302 were plausibly associated with blood pressure.
Article Synopsis
- The study investigates the genetic factors contributing to the poor prognosis of esophageal squamous cell carcinoma (ESCC) by analyzing somatic mutations from tumor-normal sample pairs.
- Researchers identified mutations in multiple genes, notably VANGL1, which were shown to enhance cell growth, and other significant genes linked to survival rates in ESCC patients.
- Functional experiments indicated that certain genes, including miR-4707-5p and MYBL2, play a role in promoting tumor growth and spread, offering potential targets for future treatments.
Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ.
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