Neural spiking for causal inference and learning.

When a neuron is driven beyond its threshold, it spikes. The fact that it does not communicate its continuous membrane potential is usually seen as a computational liability. Here we show that this spiking mechanism allows neurons to produce an unbiased estimate of their causal influence, and a way of approximating gradient descent-based learning.

Three aspects of representation in neuroscience.

Neuroscientists often describe neural activity as a representation of something, or claim to have found evidence for a neural representation, but there is considerable ambiguity about what such claims entail. Here we develop a thorough account of what 'representation' does and should do for neuroscientists in terms of three key aspects of representation. (i) Correlation: a neural representation correlates to its represented content; (ii) causal role: the representation has a characteristic effect on behavior; and (iii) teleology: a goal or purpose served by the behavior and thus the representation.

Efficient Spike-Driven Learning With Dendritic Event-Based Processing.

A critical challenge in neuromorphic computing is to present computationally efficient algorithms of learning. When implementing gradient-based learning, error information must be routed through the network, such that each neuron knows its contribution to output, and thus how to adjust its weight. This is known as the credit assignment problem.

Reconfiguring Motor Circuits for a Joint Manual and BCI Task.

Designing brain-computer interfaces (BCIs) that can be used in conjunction with ongoing motor behavior requires an understanding of how neural activity co-opted for brain control interacts with existing neural circuits. For example, BCIs may be used to regain lost motor function after stroke. This requires that neural activity controlling unaffected limbs is dissociated from activity controlling the BCI.

Quantifying How Staining Methods Bias Measurements of Neuron Morphologies.

The process through which neurons are labeled is a key methodological choice in measuring neuron morphology. However, little is known about how this choice may bias measurements. To quantify this bias we compare the extracted morphology of neurons collected from the same rodent species, experimental condition, gender distribution, age distribution, brain region and putative cell type, but obtained with 19 distinct staining methods.

Analysis of Neuronal Spike Trains, Deconstructed.

As information flows through the brain, neuronal firing progresses from encoding the world as sensed by the animal to driving the motor output of subsequent behavior. One of the more tractable goals of quantitative neuroscience is to develop predictive models that relate the sensory or motor streams with neuronal firing. Here we review and contrast analytical tools used to accomplish this task.

Dimensionality reduction in neuroscience.

The nervous system extracts information from its environment and distributes and processes that information to inform and drive behaviour. In this task, the nervous system faces a type of data analysis problem, for, while a visual scene may be overflowing with information, reaching for the television remote before us requires extraction of only a relatively small fraction of that information. We could care about an almost infinite number of visual stimulus patterns, but we don't: we distinguish two actors' faces with ease but two different images of television static with significant difficulty.

A reaction-diffusion model of cholinergic retinal waves.

Prior to receiving visual stimuli, spontaneous, correlated activity in the retina, called retinal waves, drives activity-dependent developmental programs. Early-stage waves mediated by acetylcholine (ACh) manifest as slow, spreading bursts of action potentials. They are believed to be initiated by the spontaneous firing of Starburst Amacrine Cells (SACs), whose dense, recurrent connectivity then propagates this activity laterally.

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.

Background: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development.