Publications by authors named "Benjamin L Deck"
Background: Cognitive control processes, including those involving frontoparietal networks, are highly variable between individuals, posing challenges to basic and clinical sciences. While distinct frontoparietal networks have been associated with specific cognitive control functions such as switching, inhibition, and working memory updating functions, there have been few basic tests of the role of these networks at the individual level.
Methods: To examine the role of cognitive control at the individual level, we conducted a within-subject excitatory transcranial magnetic stimulation (TMS) study in 19 healthy individuals that targeted intrinsic ("resting") frontoparietal networks.
Cognitive control (CC) is essential for problem-solving in everyday life, and CC-related deficits occur alongside costly and debilitating disorders. The tri-partite model suggests that CC comprises multiple behaviors, including switching, inhibiting, and updating. Activity within the fronto-parietal control network B (FPCN-B), the dorsal attention network (DAN), the cingulo-opercular network (CON), and the lateral default-mode network (L-DMN) is related to switching and inhibiting behaviors.
View Article and Find Full Text PDFThis study examined whether an alteration in the effort-reward relationship, a theoretical framework based on cognitive neuroscience, could explain cognitive fatigue. Forty persons with MS and 40 healthy age- and education-matched cognitively healthy controls (HC) participated in a computerized switching task with orthogonal high- and low-demand (effort) and reward manipulations. We used the Visual Analog Scale of Fatigue (VAS-F) to assess subjective state fatigue before and after each condition during the task.
View Article and Find Full Text PDFTranscranial magnetic stimulation (TMS) is used in several FDA-approved treatments and, increasingly, to treat neurological disorders in off-label uses. However, the mechanism by which TMS causes physiological change is unclear, as are the origins of response variability in the general population. Ideally, objective in vivo biomarkers could shed light on these unknowns and eventually inform personalized interventions.
View Article and Find Full Text PDFObjective: The objective of this study was to determine the frequency and impact of subjective cognitive complaint (SCC) in Parkinson's disease (PD) patients with normal cognition.
Methods: Patients with PD with expert consensus-determined normal cognition at baseline were asked a single question regarding the presence of SCC. Baseline (N = 153) and longitudinal (up to 4 follow-up visits during a 5-year period; N = 121) between-group differences in patients with PD with (+SCC) and without (-SCC) cognitive complaint were examined, including cognitive test performance and self-rated and informant-rated functional abilities.
Background: The Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15) assesses cognition-related instrumental activities of daily living (IADL) in Parkinson's disease (PD).
Objectives: To assess the degree and predictors of disagreement between patients (PT) and knowledgeable informants (KI) on the PDAQ-15.
Methods: We recruited 254 PT and KI pairs (PT-KI), determined predictors of agreement, and compared scores to a performance-based functional measure (Direct Assessment of Functional Status [DAFS]; N = 61).
Background: The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood.
Objectives: Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD.
Methods: Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally.