Publications by authors named "Benjamin L Carpenter"
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.
Gabriela M Webb Jhomary Molden Kathleen Busman-Sahay Shaheed Abdulhaqq Helen L Wu Benjamin L Carpenter
PLoS Pathog
March 2020
Article Synopsis
- Antiretroviral therapy (ART) effectively controls HIV but does not cure it, necessitating new strategies to eliminate latent HIV reservoirs.
- N-803, a human IL-15 superagonist with immune-boosting effects, shows promise as a potential "shock and kill" therapy to clear latent HIV when used alongside ART.
- In rhesus macaques, N-803 successfully activated immune cells but did not increase viral levels, indicating it may need to be combined with other treatments targeting latent virus to be effective.