Publications by authors named "Benjamin Kirm"
Microb Cell Fact
December 2013
Article Synopsis
- Erythromycin is an important antibiotic produced by Saccharopolyspora erythraea, and its biosynthesis regulation is not well understood due to a lack of regulatory genes in its gene cluster, limiting efforts to enhance production.
- Researchers identified a potential regulatory protein, SACE_5599, which has higher expression in a high-producing strain of S. erythraea and plays a significant role in erythromycin yield and sporulation.
- Overexpressing SACE_5599 led to a 32% increase in erythromycin production, highlighting its potential alongside the previously known regulator bldD for improving antibiotic biosynthesis.
