Publications by authors named "Benjamin Jean Gaborit"
Background: The role of respiratory coinfections at diagnosis of Pneumocystis jirovecii pneumonia (PcP) on clinical impact has been underestimated.
Methods: A retrospective observational study was conducted January 2011 to April 2019 to evaluate respiratory coinfections at diagnosis of PcP patients in 2 tertiary care hospitals. Coinfection was defined by identification of pathogens from P.
Background: Septic shock remains a major cause of death that can be complicated by long-term impairment in immune function. Among regulatory T (Treg) cells, the tumor necrosis factor receptor 2 positive (TNFR2pos) Treg-cell subset endorses significant immunosuppressive functions in human tumors and a sepsis mouse model but has not been investigated during septic shock in humans.
Methods: We prospectively enrolled patients with septic shock hospitalized in intensive care units (ICU).
Article Synopsis
- Amoxicillin is the primary treatment for infective endocarditis (IE) caused by certain bacteria, with doses adjusted based on patient weight.* -
- The study analyzed factors affecting how the body processes amoxicillin to create a dosing guide (nomogram) for personalized treatment.* -
- A two-compartment model was found to be the best fit for amoxicillin pharmacokinetics, leading to a new nomogram that aims to optimize drug levels in patients with IE.*
Background: Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives of this study were to assess early risk factors for severe PJP and 90-day mortality, including the broncho-alveolar lavage fluid cytology profiles at diagnosis.
Methods: We prospectively enrolled all patients meeting pre-defined diagnostic criteria for PJP admitted at Nantes university hospital, France, from January 2012 to January 2017.