Publications by authors named "Benjamin J Freeland"
Context dependent substitution biases vary within the human genome.
BMC Bioinformatics
September 2010
Article Synopsis
- The assumption that nucleotide positions evolve independently is overly simplistic and can lead to significant biases in evolutionary models.
- A new method was developed to identify and analyze substitution patterns in DNA, highlighting biases caused by nucleotide context ranging from 2 to 5 base pairs.
- Findings reveal that these biases are substantial, vary across the genome, and differ between various genomic elements like transposons and genes.