Publications by authors named "Benjamin J Eide"
Front Microbiol
December 2017
Article Synopsis
- Bacteria use a two-component signal transduction system to regulate gene expression based on phosphate levels, with the tuberculosis-causing bacterium needing this system for its virulence and resistance to drugs.
- The study focused on proteins similar to PhoU, revealing that both PhoU1 and PhoU2 work together to inhibit the SenX3-RegX3 system, especially when phosphate is abundant, with their deletion leading to increased gene expression.
- Through genome sequencing of deletion mutants, the researchers found that the absence of PhoU proteins caused reliance on mutations that disrupt the phosphate transporter, indicating that the PhoU proteins help manage both phosphate signaling and uptake.
