Publications by authors named "Benjamin Hugues"
Article Synopsis
- FDG-PET/CT is valuable for diagnosing infective endocarditis (IE) and detecting additional septic sites, with prior studies revealing osteoarthritic septic grafts (OASGs) in 19.1% of IE patients.
- A larger study included 174 patients suspected of IE, finding OASGs in 27.6% of them, predominantly located in the spine, with 43.8% of cases being asymptomatic.
- The presence of OASGs was linked to musculoskeletal pain and tricuspid valve involvement, indicating that early identification could influence antibiotic treatment and orthopedic management.
Introduction: Several immune-mediated side effects have been reported with COVID-19 vaccines, including myocarditis.
Case Description: A 27-year-old woman with a past medical history of mild COVID-19, developed adult-onset Still's disease (AOSD) with salmon-pink flagellate erythema, polyarthritis, a sore throat, myocarditis and haemophagocytic lymphohistiocytosis after receiving two doses of the BNT162b2 vaccine (Pfizer, BioNTech). Despite the initial efficacy of high-dose pulses of methylprednisolone, inflammatory markers rose as soon as de-escalation of corticosteroids was attempted, warranting initiation of biologics targeting the interleukin (IL)-1/6 axis, which allowed sustained remission of the disease despite withdrawal of corticosteroids.
Background: Recent advances in knowledge of the pathogenesis of rheumatoid arthritis (RA) has led to promoting very early intervention.
Objectives: To assess the efficacy of therapeutic interventions in preventing or delaying RA onset with a systematic literature review (SLR) and meta-analysis (MA).
Methods: The SLR aimed to include all reports of randomised controlled trials of disease-modifying antirheumatic drugs or glucocorticoids used in patients presenting genetic and/or environmental risk factors for RA and/or systemic autoimmunity associated with RA, and/or symptoms without clinical arthritis and/or unclassified arthritis and in patients with RA.