Safety and Efficacy of Synthetic Mesh for Ventral Hernia Repair in a Contaminated Field.

Background: Controversy remains about appropriate mesh selection during ventral hernia repair (VHR) in a contaminated field. Fear of mesh infection has led to increased use of biologic and absorbable synthetic meshes rather than permanent synthetic mesh in these cases. We report the safety and efficacy of permanent synthetic mesh during contaminated VHR.

MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.

Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1R) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1R). Furthermore, PTH upregulates MMP14 in human bone cultures and in Ot-enriched bones from floxed control mice but not from cKOPTH1R mice.

Effect of reorientation statistics on torque response of self-propelled particles.

We consider the dynamics of self-propelled particles subject to external torques. Two models for the reorientation of self-propulsion are considered: run-and-tumble particles and active Brownian particles. Using the standard tools of nonequilibrium statistical mechanics we show that the run and tumble particles have a more robust response to torques.