Bicarbonate as a predictor of successful insulin transition in critically ill patients with diabetic ketoacidosis: A retrospective cohort study.

Background: Treatment of diabetic ketoacidosis with intravenous insulin is effective but resource intensive. Treatment guidelines recommend transitioning to subcutaneous insulin when the anion gap closes, but transition failures due to recrudescent ketoacidosis are common despite adherence to treatment protocols following such guidance.

Study Objective: The primary objective of our study was to evaluate the ability of serum bicarbonate levels of ≤16 mEq/L to predict intravenous to subcutaneous transition failures among those with a normal anion gap at the time of transition.

Reducing Diabetic Ketoacidosis Intensive Care Unit Admissions Through an Electronic Health Record-Driven, Standardized Care Pathway.

Diabetic ketoacidosis (DKA) is a common condition, with wide variation in admission location and clinical practice. We aimed to decrease intensive care unit (ICU) admission for DKA by implementing a standardized, electronic health record-driven clinical care pathway that used subcutaneous insulin, rather than a continuous insulin infusion, for patients with nonsevere DKA. This is a retrospective, observational preintervention to postintervention study of 214 hospital admissions for DKA that evaluated the effect of our intervention on clinical, safety, and cost outcomes.

Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.

Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g.

Benefit of ribose in a patient with fibromyalgia.

Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.

Organ pipe radiant modes of periodic micromachined silicon surfaces.

In recent studies on small pyroelectric thermal anemometers with roughened surfaces we showed that one of the most widely used heat transfer models yielded calculated anemometer responses for flow and geometric behaviour that agreed functionally with observations, but were significantly smaller than the experimental data. As the first stage in investigating the role of small structures in heat transfer, we initiated a study of emittance from deep gratings. Here we report measurements at 400 °C of infrared (3 µm⩽λ⩽14 µm), normal, s- and p-polarized spectral emittances of 45 µm deep, near square-wave gratings of heavily phosphorus doped (110) silicon (P content ∼5 × 10 cm).