Publications by authors named "Benjamin Ferrier"
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.
J Mammary Gland Biol Neoplasia
July 2023
Article Synopsis
- - The adaptor proteins NCK1 and NCK2 are important for various biological functions, especially in the developing mouse mammary gland, showing different expression patterns with Nck1 present in many cell types and Nck2 mainly in hormone-sensing luminal cells.
- - Knockout studies of Nck1 and Nck2 in mice revealed significant developmental issues in ductal growth at early ages, with unique patterns of cell proliferation and gene expression changes at different developmental stages (5, 8, and 12 weeks).
- - These findings highlight the essential roles of NCK proteins in proper mammary gland development, indicating that misregulation of these proteins could potentially contribute to breast cancer progression and metastasis.