Multiplex antibiotic susceptibility testing of urinary tract infections using an electrochemical lab-on-a-chip.

Urinary tract infections (UTIs) represent the most prevalent type of outpatient infection, with significant adverse health and economic burdens. Current culture-based antibiotic susceptibility testing can take up to 72 h resulting in ineffective prescription of broad-spectrum antibiotics, poor clinical outcomes and development of further antibiotic resistance. We report an electrochemical lab-on-a-chip (LOC) for testing samples against seven clinically-relevant antibiotics.

Comparative study of the analysis of seized samples by GC-MS, H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting.

Rapid analysis of surrendered or seized drug samples provides important intelligence for health (e.g. treatment or harm reduction), and custodial services.

Facemasks Block Lower Visual Field in Youth Ice Hockey.

Wearing a facemask (FM) reduces the spread of COVID-19, but it also blocks a person's lower visual field. Many new public safety rules were created in response to COVID-19, including mandated FM wearing in some youth sports like youth ice hockey. We hypothesized that FM wearing in youth hockey players obstructs the lower field of view and may impact safety.

Rapid antibiotic susceptibility testing using resazurin bulk modified screen-printed electrochemical sensing platforms.

Urinary tract infections (UTIs) are one of the most common types of bacterial infection. UTIs can be associated with multidrug resistant bacteria and current methods of determining an effective antibiotic for UTIs can take up to 48 hours, which increases the chances of a negative prognosis for the patient. In this paper we report for the first time, the fabrication of resazurin bulk modified screen-printed macroelectrodes (R-SPEs) demonstrating them to be effective platforms for the electrochemical detection of antibiotic susceptibility in complicated UTIs.

Effect of timing delay between visual and vestibular stimuli on heading perception.

Heading direction is perceived based on visual and inertial cues. The current study examined the effect of their relative timing on the ability of offset visual headings to influence inertial perception. Seven healthy human subjects experienced 2 s of translation along a heading of 0°, ±35°, ±70°, ±105°, or ±140°.

A Protocol for Imaging of Cochlear Implantation.

Objectives: Correct electrode placement is a challenge of cochlear implant surgery, which occurs because electrode position cannot be directly visualized. This work aims to 1) develop a protocol for a practical, consistent, single view plain radiograph able to be used to confirm cochlear implantation, 2) confirm its usefulness on patients, and 3) confirm its usefulness for identifying misplaced electrodes in cadaveric ears.

Study Design: Imaging procedure and quality improvement initiative.

Common causation and offset effects in human visual-inertial heading direction integration.

Movement direction can be determined from a combination of visual and inertial cues. Visual motion (optic flow) can represent self-motion through a fixed environment or environmental motion relative to an observer. Simultaneous visual and inertial heading cues present the question of whether the cues have a common cause (i.

Superior Semicircular Canal Dehiscence Syndrome.

Superior canal dehiscence syndrome (SCDS) is a vestibular disorder caused by a pathologic third window into the labyrinth that can present with autophony, sound- or pressure-induced vertigo, and chronic disequilibrium among other vestibulocochlear symptoms. Careful history taking and examination in conjunction with appropriate diagnostic testing can accurately diagnose the syndrome. Key examination techniques include fixation-suppressed ocular motor examination investigating for sound- or pressure-induced eye movements in the plane of the semicircular canal.

Effect of range of heading differences on human visual-inertial heading estimation.

Both visual and inertial cues are salient in heading determination. However, optic flow can ambiguously represent self-motion or environmental motion. It is unclear how visual and inertial heading cues are determined to have common cause and integrated vs perceived independently.

Effect of vibration during visual-inertial integration on human heading perception during eccentric gaze.

Heading direction is determined from visual and inertial cues. Visual headings use retinal coordinates while inertial headings use body coordinates. Thus during eccentric gaze the same heading may be perceived differently by visual and inertial modalities.

Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine.

Objective: To measure the static visual vertical and the effect of visual rotation on the perception of visual vertical in migraine and vestibular migraine subjects. By so doing, we may better understand the vestibular contribution to the pathophysiology of migraine, as well as the capacity for visual compensation.

Methods: The perception of visual vertical in the presence of static and dynamic visual cues was prospectively studied in 10 subjects with migraine, 6 subjects with vestibular migraines, and 10 controls.

Effect of eye position during human visual-vestibular integration of heading perception.

Visual and inertial stimuli provide heading discrimination cues. Integration of these multisensory stimuli has been demonstrated to depend on their relative reliability. However, the reference frame of visual stimuli is eye centered while inertia is head centered, and it remains unclear how these are reconciled with combined stimuli.

An adaptive vestibular rehabilitation technique.

Objectives/hypothesis: There is a large variation in vestibular rehabilitation (VR) results depending on type of therapy, adherence, and the appropriateness for the patient's level of function. A novel adaptive vestibular rehabilitation (AVR) program was developed and evaluated.

Study Design: Technology and procedure development, and prospective multicenter trial.

Roll vection in migraine and controls using inertial nulling and certainty estimate techniques.

Vection is an illusory perception of self-motion that occurs when a visual motion is presented in the majority of the visual field. We used certainty estimate (CE) and inertial nulling (IN) techniques to study the effect of visual stimuli on roll perception in 10 migraine and 9 control subjects. A visual roll stimulus was presented for 1 to 8s.

Perception of combined translation and rotation in the horizontal plane in humans.

Thresholds and biases of human motion perception were determined for yaw rotation and sway (left-right) and surge (fore-aft) translation, independently and in combination. Stimuli were 1 Hz sinusoid in acceleration with a peak velocity of 14°/s or cm/s. Test stimuli were adjusted based on prior responses, whereas the distracting stimulus was constant.

Frequency and Demographics of Gentamicin Use.

Objective: To understand how aminoglycosides such as gentamicin are used in a tertiary care setting. To familiarize otologists with the demographics and risk factors associated with gentamicin use at major medical centers to allow the possibility of early intervention.

Study Design: Retrospective review of existing clinical data.

Influence of Visual Motion, Suggestion, and Illusory Motion on Self-Motion Perception in the Horizontal Plane.

A moving visual field can induce the feeling of self-motion or vection. Illusory motion from static repeated asymmetric patterns creates a compelling visual motion stimulus, but it is unclear if such illusory motion can induce a feeling of self-motion or alter self-motion perception. In these experiments, human subjects reported the perceived direction of self-motion for sway translation and yaw rotation at the end of a period of viewing set visual stimuli coordinated with varying inertial stimuli.

Human Vection Perception Using Inertial Nulling and Certainty Estimation: The Effect of Migraine History.

Vection is an illusory perception of self-motion that can occur when visual motion fills the majority of the visual field. This study examines the effect of the duration of visual field movement (VFM) on the perceived strength of self-motion using an inertial nulling (IN) and a magnitude estimation technique based on the certainty that motion occurred (certainty estimation, CE). These techniques were then used to investigate the association between migraine diagnosis and the strength of perceived vection.

Coordinates of Human Visual and Inertial Heading Perception.

Heading estimation involves both inertial and visual cues. Inertial motion is sensed by the labyrinth, somatic sensation by the body, and optic flow by the retina. Because the eye and head are mobile these stimuli are sensed relative to different reference frames and it remains unclear if a perception occurs in a common reference frame.

The influence of head and body tilt on human fore-aft translation perception.

The tilt-translation ambiguity occurs because acceleration due to translation cannot be differentiated from gravitational acceleration. Head tilt can occur independent of body tilt which further complicates the problem. The tilt-translation ambiguity is examined for fore-aft (surge) translation with head and/or body orientations that are tilted in pitch 10° forward or backward.