Publications by authors named "Benjamin Cline"

Photodynamic therapy (PDT) is an emerging treatment option for cancer. In PDT, photosensitizers are delivered to tumors and stimulated by light to generate reactive oxygen species (ROS)-most importantly singlet oxygen (O)-to damage tumor cells or induce tissue ischemia. PDT is associated with a low level of systemic toxicity because photosensitizers are usually pharmaceutically inactive in the dark and photoirradiation is applied only to tumor areas in the procedure.

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Iodine has shown promise in enhancing radiotherapy. However, conventional iodine compounds show fast clearance and low retention inside cancer cells, limiting their application as a radiosensitizer. Herein, we synthesize poly(maleic anhydride--1-octadecene) coated KI nanoparticles (PMAO-KI NPs) and evaluate their potential for enhancing radiotherapy.

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Following publication of this article, the authors noticed that an incorrect affiliation was assigned to the author "Lucie Muchová". The original article has now been updated so that the author "Lucie Muchová" is associated with the "Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Kateřinská 32, 120 00 Prague, Czech Republic". This has been corrected in both the PDF and HTML versions of the article.

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Article Synopsis
  • The study investigates how different wavelengths of light affect the breakdown of bilirubin, a substance that can accumulate in the body and cause jaundice.
  • Using controlled laboratory conditions, the researchers exposed bilirubin solutions to specific light wavelengths (390-530 nm) to measure how effectively they caused bilirubin to degrade.
  • Results showed that the most efficient light for breaking down bilirubin was in the 490-500 nm range, with notable differences in the rate of degradation based on the wavelength used.
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Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X-ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest.

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This study investigated the effectiveness of simple-to-implement adjustments of phototherapy devices on irradiance levels in a cross-section of Nigerian hospitals. A total of 76 phototherapy devices were evaluated in 16 hospitals while adjustments were implemented for a subset of 25 devices for which consent was obtained. The mean irradiance level was 7.

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Phototherapy is the treatment of choice to reduce the severity of neonatal unconjugated hyperbilirubinemia regardless of its etiology. Its implementation requires a technical framework that conforms to existing evidence-based guidelines that promote its safer and effective use worldwide. Optimal use of phototherapy has been defined by specific ranges of total serum bilirubin thresholds configured to an infant's postnatal age (in hours) and potential risk for bilirubin neurotoxicity.

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