Publications by authors named "Benjamin Bowling"
Article Synopsis
- - The growing interest in neuropathic pain related to low back-related leg pain highlights the need for accurate diagnostic methods, as proper identification is crucial for effective treatment management.
- - This systematic review aims to evaluate the effectiveness of various diagnostic investigations for recognizing neuropathic pain in patients suffering from low back-related leg pain by following established research protocols.
- - The study will involve extensive searches across multiple databases and journals, with independent reviewers assessing the quality and biases of the included research to either perform a meta-analysis or provide a narrative synthesis if data pooling is not feasible.
Although clearly effective in acute promyelocytic leukemia (APL), arsenic trioxide (ATO) demonstrates little clinical benefit as a single agent in the treatment of non-APL hematological malignancies. We screened a library of 2000 marketed drugs and naturally occurring compounds to identify agents that potentiate the cytotoxic effects of ATO in leukemic cells. Here, we report the identification of three isothiocyanates (sulforaphane, erysolin and erucin) found in cruciferous vegetables as enhancers of ATO cytotoxicity.
View Article and Find Full Text PDFPurpose: Current standard chemotherapeutic regimens for malignant melanoma are unsatisfactory. Although in vitro studies of arsenic trioxide (ATO) have demonstrated promise against melanoma, recent phase II clinical trials have failed to show any significant clinical benefit when used as a single agent. To enhance the efficacy of ATO in the treatment of melanoma, we sought to identify compounds that potentiate the cytotoxic effects of ATO in melanoma cells.
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